"Our research team has long hoped to be able to target radiotherapy in this way," says oncologist Håkan Andersson from Sahlgrenska University Hospital, who is leading the research alongside professor Ragnar Hultborn from the Sahlgrenska Academy and radiation physicist Lars Jacobsson.
"There is a good chance of this treatment working, as the study indicates that a sufficient amount of the active substance reaches the tumour cells in the abdominal cavity without any measurable side-effects."
The aim of this initial patient study, just published in the Journal of Nuclear Medicine, was to study the substance's distribution in the body and any side-effects in nine women with ovarian cancer.
"We have previously seen that mice with ovarian cancer given this treatment are generally cured without serious side-effects, so we hope that this will become an established and effective treatment for women with metastatic ovarian cancer," says Ragnar Hultborn, professor of oncology at the University of Gothenburg's Sahlgrenska Academy. "But it will still be several years of development."
The research is being funded partly by the Swedish Research Council and the Swedish Cancer Society.
"In our next study, 80 women with ovarian cancer will receive this treatment as a supplement to their ordinary treatment so that we can scientifically test whether the effect is as good in real patients as the animal studies indicate," Håkan Andersson says.OVARIAN CANCER
Partners in clinical research The Sahlgrenska Academy is the University of Gothenburg's health sciences faculty, while Sahlgrenska University Hospital is one of northern Europe's largest hospitals. The two institutions have almost 300 different joint research projects under way. Their strongest research fields include obesity with cardiovascular research and diabetes, biomaterials, pharmacology, neuroscience, paediatrics, epidemiology, rheumatology and microbiology.
Helena Aaberg | idw
Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University
Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
27.02.2017 | Materials Sciences
27.02.2017 | Interdisciplinary Research
27.02.2017 | Life Sciences