The failure of any one of these tissue systems can cause serious health issues, even death. When components of the organ are fixed, typically the organ functions better. For instance, unclogging a blocked artery with a balloon stent improves blood circulation to and from the heart.
Henry Ford Hospital researcher Fred Nelson, M.D., suggests that viewing the knee as an organ in the same way doctors examine the heart for heart disease could lead to better therapies for treating osteoarthritis, one of the five leading causes of disability in elderly men and women. The American Academy of Orthopaedic Surgeons asserts that the risk for disability from osteoarthritis of the knee is as great as that from cardiovascular disease.
An exhibit that in part examines degenerative knee arthritis as an organ in failure will be displayed at the annual meeting of the American Academy of Orthopaedic Surgeons Feb. 15-18 in San Diego.
"For years we've looked at the aging knee strictly from a mechanical perspective recognizing the critical role of articular cartilage. We keep forgetting that other structures about the knee are also affected," says Dr. Nelson, director of Henry Ford's Osteoarthritis Center. "The underpinnings of research about a degenerative disease like osteoarthritis should take into account the bone, cartilage, ligaments, nerves and circulating chemicals and how these components collectively work together to affect the function of the knee."
Osteoarthritis of the knee is a leading cause of disability and loss of independence. It is most typically a slow, progressively degenerative disease in which the joint cartilage gradually wears away due to trauma, aging or infection. As the cartilage thins, the surrounding bone may thicken. Often bones rub against one another and may be the individual's source of pain. In most cases, normal activity becomes painful and difficult.
Current treatments include drug therapies like anti-inflammatory medication or pain relievers, physical therapy, support devices, health and behavioral modifications such as weight loss, and joint replacement surgery.
"Our strategies are directed at anti-inflammatory and pain medications. Yet, we don't look at the origins of pain, which can be a product of dysfunction of joint tissue, bone and nerves," Dr. Nelson says.
"The feed back of nerve signaling can have a direct effect on the cartilage cell itself. Knowledge of the back and forth messaging between the tissue components may lead to better interventions for pain. But we can't know that until we start looking at the knee with a broader view."
The exhibit is funded by the Orthopaedic Research Society.
David Olejarz | EurekAlert!
Improving memory with magnets
28.03.2017 | McGill University
Graphene-based neural probes probe brain activity in high resolution
28.03.2017 | Graphene Flagship
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
28.03.2017 | Life Sciences
28.03.2017 | Information Technology
28.03.2017 | Physics and Astronomy