Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Transplanted neurons develop disease-like pathology in Huntington's patients

21.07.2009
The results of a recent study published in PNAS question the long-term effects of transplanted cells in the brains of patients suffering from Huntington's disease.

This study, conducted jointly by Dr. Francesca Cicchetti of Université Laval in Quebec, Canada, Dr. Thomas B. Freeman of the University of South Florida, USA, and colleagues provides the first demonstration that transplanted cells fail to offer a long-term replacement for degenerating neurons in patients with Huntington's disease.

Huntington's disease is a neurodegenerative disease of genetic origin that targets a particular type of neuron. The loss of these neurons is responsible for the appearance of involuntary movements as well as cognitive and psychiatric impairments. Over a decade ago, Dr. Thomas Freeman of the University of South Florida initiated a clinical trial of neural cell transplantation in Huntington's diseased patients in an attempt to alleviate the dreadful symptoms that characterize this disease.

Some patients demonstrated some mild, transient clinical benefits that lasted for about 2 years. However, the loss of functional recovery after this indicated that graft survival and functionality may be jeopardized long- term.

This post-mortem study of 3 cases is the first demonstration that 1) graft survival is indeed attenuated long-term, 2) grafts undergo degeneration that resembles the pathology observed in Huntington's disease, and 3) the brain's inflammatory response could contribute to the compromised survival of grafted cells. The authors also demonstrated that cortical neurons that develop Huntington's disease synapse on the grafts and may cause neurotoxicity to healthy cells, inducing grafted neuronal cell death.

Despite the excitement regarding cell transplantation therapy utilizing embryonic or stem cells, these results raise concerns for the therapeutic potential of transplantation as a treatment option for Huntington's disease. However, these observations suggest new potential mechanisms involved in the development of the disease. A more in-depth investigation could lead to the development of novel therapeutic strategies. The control of patient immune and inflammatory responses holds therapeutic potential, and Cicchetti et al. are continuing their research in that direction.

Dr. Francesca Cicchetti is a professor in the Department of Psychiatry/Neuroscience at Université Laval and a researcher in neurobiology at le Centre hospitalier universitaire de Québec. She is directing a research laboratory focused on understanding neuronal degeneration and developing therapeutic strategies for neurodegenerative diseases.

Dr. Thomas B. Freeman is a neurosurgeon, director of clinical research, and medical director of the Center of Excellence for Aging and Brain Repair at the University of South Florida.

This work includes the scientific contribution of the following authors:
Samuel Saporta (University of South Florida)
Robert Hauser (Parkinson's Disease and Movement Disorders Center, National Parkinson's Foundation Center of Excellence, University of South Florida)
Martin Parent (Groupe de recherche sur le système nerveux central [GRSNC])
Martine Saint-Pierre (Centre de Recherche du CHUL [CHUQ])
Paul Sanberg (University of South Florida)
Xiao Li (Emory University School of Medicine)
John Parker (University of Louisville Health Sciences Center)
Yaping Chu (Rush University Medical Center)
Elliot Mufson (Rush University Medical Center)
Jeffrey Kordower (Rush University Medical Center)
Information:
Francesca Cicchetti
Centre de Recherche du CHUL (CHUQ), Unité de Neurosciences,Canada
Université Laval
Tel.: 418-656-4141, ext. 48853
Tel.:418-262-9122
Francesca.Cicchetti@crchul.ulaval.ca
Thomas B. Freeman,
University of South Florida, USA
Tel.: 813-259-0889
Tel.: 813-389-0679 tfreeman@health.usf.edu

Sarah Sanchez | EurekAlert!
Further information:
http://www.ulaval.ca

More articles from Health and Medicine:

nachricht Speed data for the brain’s navigation system
06.12.2016 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Simple processing technique could cut cost of organic PV and wearable electronics

06.12.2016 | Materials Sciences

3-D printed kidney phantoms aid nuclear medicine dosing calibration

06.12.2016 | Medical Engineering

Robot on demand: Mobile machining of aircraft components with high precision

06.12.2016 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>