"Serious behavioral problems interfere with everyday living for children and their families," said senior author on the study Lawrence Scahill, professor at Yale University School of Nursing and the Child Study Center. "Decreasing these serious behavioral problems results in children who are more able to manage everyday living."
Scahill and his team completed a federally funded multi-site trial on 124 children ages 4 to 13 with autism spectrum disorders at three U.S. sites including Yale, Ohio State University, and Indiana University. In addition to autism spectrum disorders, children in the study had serious behavioral problems, including multiple and prolonged tantrums, aggression, and/or self-injurious behavior on a daily basis.
The children in the study were randomly assigned to medication alone for six months or medication plus a structured training program for their parents for six months. Parent training included regular visits to the clinic to teach parents how to respond to behavior problems to help children adapt to daily living situations. The study medication, risperidone, is approved for the treatment of serious behavioral problems in children with autism.
"In a previous report from this trial, we showed that the combined treatment was superior to medication alone in reducing the serious behavioral problems," said Scahill. "In the current report, we show that combination treatment was better than medication alone on measures of adaptive behavior. We note that both groups—medication alone and combined treatment group—demonstrated improvement in functional communication and social interaction. But the combined group showed greater improvement on several measures of everyday adaptive functioning."
Based on these findings, Scahill and his team are now conducting a study that uses parent training as a stand-alone strategy in treating younger children with autism spectrum disorders. This study is being conducted at Yale and four other medical centers across the country. The investigators also plan to publish the parent training manuals as a way to share this intervention with the public.
Other authors on the study included Christopher J. McDougle, Michael G. Aman, Cynthia Johnson, Benjamin Handen, Karen Bearss, James Dziura, Eric Butter, Naomi G. Swiezy, L. Eugene Arnold, Kimberly A. Stigler, Denis D. Sukhodolsky, Luc Lecavalier, Stacie L. Pozdol, Roumen Nikolov, Jill A. Hollway, Patricia Korzekwa, Allison Gavaletz, Arlene E. Kohn, Kathleen Koenig, Stacie Grinnon, James A. Mulick, Sunkyung Yu, and Benedetto Vitiello.
The National Institute of Mental Health funded the study. The work was also funded, in part, by the Yale Clinical and Translational Science Award (CTSA) grant from the National Center for Research Resources at the National Institutes of Health.
Citation: J. Am. Acad. Child Adolesc. Psychiatry, Vol. 51, No. 2 (February 2012)
Karen N. Peart | EurekAlert!
New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia
New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
18.08.2017 | Life Sciences
18.08.2017 | Physics and Astronomy
18.08.2017 | Materials Sciences