Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Traffic-related air pollution associated with changes in right ventricular structure and function

07.03.2014

Exposure to high levels of traffic-related air pollution is associated with changes in the right ventricle of the heart that may contribute to the known connection between air pollution exposure and heart disease, according to a new study.

"Although the link between traffic-related air pollution and left ventricular hypertrophy, heart failure, and cardiovascular death is established, the effects of traffic-related air pollution on the right ventricle have not been well studied," said lead author Peter Leary, MD, MS, of the University of Washington Medical Center in Seattle. "Using exposure to nitrogen dioxide as a surrogate for exposure to traffic-related air pollution, we were able to demonstrate for the first time that higher levels of exposure were associated with greater right ventricular mass and larger right ventricular end-diastolic volume. Greater right ventricular mass is also associated with increased risk for heart failure and cardiovascular death."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

The study involved 3,896 participants who were free of clinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis and who underwent cardiac magnetic resonance imaging (MRI). Using estimated exposure to outdoor oxides of nitrogen at the homes of participants over the year preceding MRI, the authors found that increased exposure to nitrogen dioxide was associated with an approximately 1.0 g (5 percent) increase in right ventricular mass and a 4.1 mL (3%) increase in right ventricular end-diastolic volume.

These relationships remained after accounting for differences among participants in cardiovascular risk factors, left ventricular mass and volume, markers of inflammation, lung disease and socioeconomic status.

The authors note that this type of study can be limited in several ways. Specifically, estimates of air pollution exposure are not perfect and it remains possible that something related to air pollution, but not air pollution itself (known as confounding), was responsible for the association. For these reasons and others, this study cannot prove that traffic-related air pollution causes changes in the right heart, but does strongly suggest the relationship.

"The morphologic changes in the right ventricle of the heart that we found with increased exposure to nitrogen dioxide add to the body of evidence supporting a connection between traffic-related air pollution and cardiovascular disease," said Dr, Leary. "The many adverse effects of air pollution on human health support continued efforts to reduce this burden."

###

About the American Journal of Respiratory and Critical Care Medicine:

With an impact factor of 11.041, the AJRRCM is a peer-reviewed journal published by the American Thoracic Society. It aims to publish the most innovative science and the highest quality reviews, practice guidelines and statements in the pulmonary, critical care and sleep-related fields.

Founded in 1905, the American Thoracic Society is the world's leading medical association dedicated to advancing pulmonary, critical care and sleep medicine. The Society's 15,000 members prevent and fight respiratory disease around the globe through research, education, patient care and advocacy.

Nathaniel Dunford | EurekAlert!
Further information:
http://www.thoracic.org

Further reports about: MRI Medicine Respiratory Thoracic air dioxide function mass nitrogen pollution structure ventricle ventricular volume

More articles from Health and Medicine:

nachricht Researchers take further steps toward development of a vaccine against tick-transmitted disease
30.07.2014 | Virginia Commonwealth University

nachricht Reducing kidney injury using a quality improvement method
30.07.2014 | The Geisel School of Medicine at Dartmouth

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

Counting down to FEBS-EMBO 2014 in Paris, France

29.07.2014 | Event News

9th European Wood-Based Panel Symposium 2014 – meeting point for the wood-based material branch

24.07.2014 | Event News

“Lens on Life” - Artists and Scientists Explore Cell Divison

08.07.2014 | Event News

 
Latest News

Siemens supports E.ON's introduction of metering systems with a smart grid platform

30.07.2014 | Press release

University of Manchester researches with Siestorage

30.07.2014 | Press release

New method provides researchers with efficient tool for tagging proteins

30.07.2014 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>