Anyone who has suffered an injury can probably remember the after-effects, including pain, swelling or redness.
These are signs that the body is fighting back against the injury. When tissue in the body is damaged, biological programs are activated to aid in tissue regeneration. An inflammatory response acts as a protective mechanism to enable repair and regeneration, helping the body to heal after injuries such as wounds and burns.
However, the same mechanism may interfere with healing in situations in which foreign material is introduced, for example when synthetics are grafted to skin for dermal repair. In such cases, the inflammation may lead to tissue fibrosis, which creates an obstacle to proper physiological function.
The research group of Arun Sharma, PhD has been working on innovative approaches to tissue regeneration in order to improve the lives of patients with urinary bladder dysfunction. Among their breakthroughs was a medical model for regenerating bladders using stem cells harvested from a donor’s own bone marrow, reported in the Proceedings of the National Academy of Sciences in 2013.
More recently, the team has developed a system that may protect against the inflammatory reaction that can negatively impact tissue growth, development and function. Self-assembling peptide amphiphiles (PAs) are biocompatible and biodegradable nanomaterials that have demonstrated utility in a wide range of settings and applications.
Using an established urinary bladder augmentation model, the Sharma Group treated a highly pro-inflammatory biologic scaffold used in a wide array of settings with anti-inflammatory peptide amphiphiles (AIF-PAs). When compared with control PAs, the treated scaffold showed regenerative capacity while modulating the innate inflammatory response, resulting in superior bladder function.
This work is published in the journal Biomaterials. Says Sharma, “Our findings are very relevant not just for bladder regeneration but for other types of tissue regeneration where foreign materials are utilized for structural support. I also envision the potential utility of these nanomolecules for the treatment of a wide range of dysfunctional inflammatory based conditions.”
Arun K. Sharma, PhD is Director of Pediatric Urological Regenerative Medicine at Ann & Robert H. Lurie Children's Hospital of Chicago; Director of Surgical Research at Stanley Manne Children’s Research Institute; Assistant Professor in the Departments of Urology and Biomedical Engineering at Northwestern University Feinberg School of Medicine and Northwestern University; and a member of the Developmental Biology Program of the research institute.
The research team includes members of the Departments of Urology and Medicine at the Feinberg School; Institute for BioNanotechnology in Medicine and the Departments of Biomedical Engineering, Materials Science and Engineering, and Chemical and Biological Engineering at Northwestern University, and the Department of Urology at Loyola University Health System.
This work was performed in collaboration with the Stupp Laboratory at the Institute for BioNanotechnology in Medicine.
Full citation: Bury MI, Fuller NJ, Meisner JW, Hofer MD, Webber MJ, Chow LW, Prasad S, Thaker H, Yue X, Menon VS, Diaz EC, Stupp SI, Cheng EY, Sharma AK. The promotion of functional urinary bladder regeneration using anti-inflammatory nanofibers. Biomaterials. Available online 18 August 2014.
Copies of this paper are available to credentialed journalists upon request; please contact Elsevier’s Newsroom at firstname.lastname@example.org or +31 20 4853564.
Biomaterials is an international journal covering the science and clinical application of biomaterials. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. Biomaterials is published by Elsevier.
Stanley Manne Children's Research Institute is the research arm of Ann & Robert H. Lurie Children's Hospital of Chicago, the pediatric teaching hospital for Northwestern University Feinberg School of Medicine. The research institute is also one of the interdisciplinary research centers and institutes of the Feinberg School, where principal investigators who are part of the research institute are full-time faculty members.
For more information contact Peggy Murphy at 773.755.7485 or email@example.com.
Peggy Murphy | Eurek Alert!
A whole-body approach to understanding chemosensory cells
13.12.2017 | Tokyo Institute of Technology
Research reveals how diabetes in pregnancy affects baby's heart
13.12.2017 | University of California - Los Angeles Health Sciences
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
13.12.2017 | Health and Medicine
13.12.2017 | Physics and Astronomy
13.12.2017 | Life Sciences