Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New theory in neuroscience by UNIST Research Team: common mechanisms in Fragile X and Down syndrome

04.10.2013
A new common mechanism in Fragile X and Down syndrome has been identified by scientists at Ulsan National Institute of Science and Technology (UNIST), Korea and published in the world leading science journal, Trends in Neurosciences (Cell Press).

A new common mechanism in Fragile X and Down syndrome has been identified by scientists at Ulsan National Institute of Science and Technology (UNIST), Korea and published in the world leading science journal, Trends in Neurosciences (Cell Press). (Title : Meeting at the crossroads: Common mechanisms in Fragile X and Down syndrome, http://dx.doi.org/10.1016/j.tins.2013.08.007)

Emerging evidence shows that the regulation of local protein synthesis in dendritic spines plays a crucial role in controlling synaptic morphogenesis and synaptic efficacy. However, scientist do not yet understand how local protein synthesis regulates dendritic spine morphology, a process that is important for learning and memory.

The research team led by Prof. Kyung-Tai Min from UNIST presented evidence that pathways controlled by DSCR1 and FMRP, genes implicated in two of the most common genetic causes of intellectual disabilities – DS and FXS converge to regulate spine morphogenesis, local protein synthesis, and neurotransmission.

Min’s research team highlighted the *previous research work published in The EMBO Journal by Prof. Min, showing that some of the proteins altered in Fragile X and Down syndrome are common molecular triggers of intellectual disability in both disorders, DS and FXS.

*Title: DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis (The EMBO Journal (2012) 31, 3655 – 3666 )

They reviewed other genes encoded by chromosome 21 that may regulate dendritic spine morphogenesis and contribute to intellectual disabilities by acting through pathways involving FMRP and DSCR1.

The research work provided an important stepping stone in understanding the multiple roles of DSCR1 in neurons and in identifying a molecule that is closely linked to intellectual disability for both syndromes.

“We will continuously investigate whether reducing FMRP in DS mouse model or elevating DSCR1 in FMRP knockout mice could restore synaptic plasticity, dendritic spine morphogenesis, and local protein synthesis will further advance our understanding of both diseases,” said Prof. Min, presenting future research plan.

“Further elucidation of the large functional protein-inter-action network that regulates local protein synthesis, spine morphogenesis, and synaptic transmission may also shed light on overlapping molecular pathways that cause intellectual disabilities in different disorders,” added Prof. Min.

This research work was supported by grants from Ulsan National Institute of Science and Technology, the Korea Ministry of Education, Science and Technology and Foundation Jerome Lejeune.

Ulsan National Institute of Science and Technology (UNIST) http://www.unist.ac.kr
Homepage of Prof. Kyung-Tai Min http://minlab.unist.ac.kr/
The original press release can be found at
https://www.unist.ac.kr/board/view.sko?boardId=Notice&boardSid=5037&menuCd=AB07002001000&contentsSid=8297&orderBy=register_dt&startPage=1&searchType=&keyword=&searchStartDt=&searchEndDt=&dataSid=2377338

Associated links
http://www.unist.ac.kr
http://minlab.unist.ac.kr
Journal information
Trends in Neurosciences (Cell Press)
Funding information
UNIST, the Korea Ministry of Education, Science and Technology and Foundation Jerome Lejeune

Eunhee Song | Research asia research news
Further information:
http://www.unist.ac.kr
http://www.researchsea.com

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>