Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

How Testosterone Protects against Inflammation

26.07.2011
Pharmacists of the University Jena analyze why men suffer more rarely from inflammatory diseases than women

It’s all down to the testosterone: men are usually more muscular than women, they have deeper voices and more body hair. And – men are less susceptible to inflammatory diseases and allergies than women. This is also due to the male sex hormones as pharmacists at the Friedrich Schiller University Jena (Germany) have shown in a recent study.

“It is mostly women who are affected by diseases like rheumatoid arthritis, psoriasis or asthma“, Professor Dr. Oliver Werz from the Jena University explains. Although this is a fact known for some time, the reasons for these differences are largely unknown. As the Jena Professor for pharmaceutical and medical chemistry and his team have revealed now, sexual hormones play an important role in this. The researchers report about this in the current edition of the scientific journal ‘FASEB Journal’ (DOI: 10.1096/fj.11-182758).

“In a series of analyses we have shown that cells from men and women react in a different manner to inflammatory stimuli,” Dr. Carlo Pergola from the Institute of Pharmacy of University Jena explains. Thus, certain immune cells of women produced nearly twice as many pro-inflammatory substances than those of men. Together with colleagues from Tübingen (Germany), Stockholm (Sweden) and Naples (Italy) the Jena researchers pursued the molecular basis for these differences and published their findings in their current study. To this aim, they isolated immune cells of male and female donors and analyzed in test tubes the activity of the enzymes responsible for the production of pro-inflammatory substances. They found that in male cells the enzyme phospholipase D is less active than in the female ones. “Interestingly, the activity of the enzyme is reduced after treatment with testosterone also in the female immune cells“, Dr. Pergola defines a crucial result.

Based on these findings, the Jena pharmacists concluded that the male sex hormones play a key role in the modulation of the immune response. This would also explain another phenomenon that has been previously noticed, that is, testosterone can protect men from arteriosclerosis.

Most importantly, the new knowledge should be taken into account in the assessment of new therapies and drugs for inflammatory diseases, Professor Werz stresses. “New therapies are usually still more often being tested on male volunteers or patients“. But the Jena study indicates now that the results derived from male subjects cannot be immediately transcribed to women. On the contrary, a ‘customized’ therapy for men and women would be important.

Original-Publication:
Pergola C. et al.: Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes. The FASEB Journal 2011 (DOI: 10.1096/fj.11-182758)
Contact:
Dr. Carlo Pergola, Prof. Dr. Oliver Werz
Institute of Pharmacy of Friedrich Schiller University Jena
Philosophenweg 14
D-07743 Jena
Tel.: 0049 3641 / 949811 or 949801
Email: carlo.pergola[at]uni-jena.de, oliver.werz[at]uni-jena.de

Ute Schönfelder | idw
Further information:
http://www.uni-jena.de/en/start_en.html

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>