Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New test announced for major killer of lung transplant patients

03.01.2011
High stem cell count after transplant predicts debilitating syndrome, U-M research finds

A lung transplant can mean a new chance at life. But many who receive one develop a debilitating, fatal condition that causes scar tissue to build up in the lungs and chokes off the ability to breathe.

University of Michigan researchers hope a new diagnostic tool they developed to predict bronchiolitis obliterans syndrome (BOS) will allow doctors to intervene earlier and, ultimately, to provide life-saving treatments.

BOS is the leading cause of death for those who survive one year after lung transplantation and more than half of recipients will develop BOS within five years. There is currently no cure.

Vibha Lama, M.D., M.S., an assistant professor of pulmonary and critical care medicine at the University of Michigan Medical School, led a team of U-M researchers who recently discovered that patients who had a high number of stem cells in their lungs six months after transplantation were much more likely to develop BOS than those with lower counts.

"Our study provides the first indication of the important role these cells play in both human repair and disease," Lama says. "It's very important from the clinical perspective because we didn't previously have any strong biomarkers for BOS."

The findings were recently published online ahead of print publication in the American Journal of Respiratory and Critical Care Medicine.

The translational study also highlights the importance of the lab-to-bedside cooperation of basic and clinical research, Lama says.

While the exact relationship between the mesenchymal stromal cells and BOS remains unclear, doctors know that most of the cells originate with the donor and not the recipient. Spikes in cell counts are seen shortly after transplantation as the body responds to the injury; those levels usually taper off, but a second rise of cell counts after about six months is linked to a patient's likelihood of developing BOS.

In 2007, Lama and her colleagues published another discovery about the stem cells, revealing that the cells reside in the transplanted organs, independent of their more commonly known association with bone marrow. That study led to the further exploration of the cells' involvement with chronic transplant rejection.

The new findings also have the potential to spur research that will help people suffering from other types of lung disease, such as idiopathic pulmonary fibrosis, known as IPF.

Having the biomarker will also allow researchers to readily identify a population of patients ideal for testing new drug interventions and therapies.

"By the time we usually diagnose BOS, there's already been a huge decline in lung function," Lama says. "If we can find the disease early, we can potentially do something about it."

Methodology: Mesenchymal stromal cells were measured in 405 bronchoalveolar lavage fluid samples obtained from 162 lung transplant recipients and patients were observed for BOS development.

Additional U-M authors: Linda Badri; Susan Murray, Sc.D.; Lyrica X. Liu; Natalie M. Walker; Andrew Flint, M.D.; Anish Wadhwa, M.D.; Kevin Chan, M.D.; Galen B. Toews, M.D.; David J. Pinksy, M.D.; Fernando J. Martinez, M.D., M.S.

Funding: The research was supported by grants from the National Institutes of Health, American Thoracic Society and Scleroderma Research Foundation.

Dr. Lama also wishes to acknowledge the generous research support of Brian and Mary Campbell, and Elizabeth Campbell Carr.

Disclosure: U-M is filling for patent protection for this test and is actively engaged in finding a commercial partner who can help bring the developments to market.

Citation: American Journal of Respiratory and Critical Care Medicine 2010, doi:10.1164/rccm.201005-0742OC

Resources: U-M Pulmonary & Critical Care Medicine, med.umich.edu/intmed/pulmonary

Ian Demsky | EurekAlert!
Further information:
http://www.umich.edu

More articles from Health and Medicine:

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

nachricht Disrupted fat breakdown in the brain makes mice dumb
19.05.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

Im Focus: Hydrogen Bonds Directly Detected for the First Time

For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.

Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

Media accreditation opens for historic year at European Health Forum Gastein

16.05.2017 | Event News

 
Latest News

New approach to revolutionize the production of molecular hydrogen

22.05.2017 | Materials Sciences

Scientists enlist engineered protein to battle the MERS virus

22.05.2017 | Life Sciences

Experts explain origins of topographic relief on Earth, Mars and Titan

22.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>