Worldwide, almost 2 million children die each year as a result of infectious diarrhoea1, however, diarrhoeal diseases are also very common in developed countries. “Diarrhoea associated intestinal disorders, such as irritable bowel syndrome (IBS), Crohn’s disease, colitis, coeliac disease and microbial infections are a major health issue in Ireland.
It is estimated that between 40,000 and 50,000 people visit their local Gastroenterology clinic each year2 seeking treatment for diarrhoea. The cost to the Irish economy in terms of healthcare costs and lost working days is immense,” commented Dr Stephen Keely, senior author on the study and Associate Director of the RCSI Molecular Medicine Lab at Beaumont Hospital.
Explaining the findings of the research study, Dr Keely said: ‘Current treatments for intestinal diseases are not targeted specifically enough and as a result can be ineffective or have serious side effects. Working with researchers in UCD and TCD, we have discovered that a type of protein, known as hydroxylases, play a key role in regulating water and salt transport in the intestines. Our experimental results suggest that by inhibiting the activity of these proteins, diarrhoea can be prevented. The discovery gives us a promising new target for the development of drugs to treat intestinal diseases that have diarrhoea as a primary symptom. Because such drugs would act directly on the cells responsible for controlling water movement in the intestine, they would potentially have better outcomes and reduced side effects for patients,” Dr Keely concluded.
The lead author on the paper is Joseph Ward who conducted the research as part of his PhD studies along with Dr Karen Lawler and Dr Keely from the Molecular Medicine Laboratories in RCSI. The team also collaborated with Prof Padraic Fallon from the Institute of Molecular Medicine, Trinity College Dublin, and Prof Cormac Taylor of the Conway Institute at University College Dublin.
This work was published in the Federation of American Societies for Experimental Biology (FASEB) Journal in October 2010 and was funded by Science Foundation Ireland and the Higher Education Authority’s Programme for Research in Third Level Institutions (PRTLI) Cycle 4, as part of the National Biophotonics Imaging Platform (NBIP) Ireland.Full bibliographic information
Jane Butler | alfa
Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University
3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg
The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
25.05.2018 | Event News
02.05.2018 | Event News
13.04.2018 | Event News
25.05.2018 | Event News
25.05.2018 | Machine Engineering
25.05.2018 | Life Sciences