Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Targeted Micro-Bubbles Detect Artery Inflammation, MU Study Finds

13.12.2012
Procedure done in pigs could potentially detect heart disease early in humans

Heart disease is a leading cause of death throughout the world. Doctors say that it is important to detect heart disease early before it becomes too serious. Now, researchers at the University of Missouri have found a way that they believe could help detect heart disease before it progresses too far as well as identify patients who are at risk for strokes.

In a study published in Medicine and Science in Sports and Exercise, Isabelle Masseau, an assistant teaching professor in the MU College of Veterinary Medicine, found that she could use targeted micro-bubbles to detect artery inflammation in pigs. She says that this procedure may help detect patients with heart disease or who are at risk for strokes before those ailments become too serious by monitoring artery inflammation, as that is an early warning sign of health problems. She says this procedure may also help monitor the effectiveness of artery inflammation treatments.

“It can be very difficult to detect early signs of heart disease, especially without the use of invasive procedures,” Masseau said. “Doctors often have to wait until serious symptoms occur, such as chest pain or heart attacks, before they are aware of a problem, and many times that is too late. Targeted micro-bubbles have the potential to be able to detect early signs of heart disease very non-invasively.”

Early signs of heart disease include inflammation on the insides of arteries, which leads to plaque buildup that could eventually result in heart attacks. Masseau was able to attach specific antibodies to tiny bubbles and then inject those bubbles into pigs with heart disease. The antibodies were able to seek out the inflammation in the pigs’ arteries and attach themselves, along with the micro-bubbles, to the inflammatory sites. Then, using an ultrasound machine, Masseau was able to detect the targeted micro-bubbles that had gathered in the arteries of pigs. She says this is the first time the procedure has been successful in large animals.
“Because this procedure was successful in pigs, it also could potentially be reproduced in humans as well,” Masseau said. “While it would still be a few years away, injecting targeted micro-bubbles into a human and then scanning them with an ultrasound would be a very simple procedure and could potentially help save lives.”

Another part of Masseau’s research involved studying pigs to observe the effects exercise has on artery inflammation. Before Masseau detected inflammation in the pigs using the targeted micro-bubbles, she submitted them to cardio exercise and measured its effect. Surprisingly, the exercise did not have any effect on reducing the arterial inflammation; however Masseau says that this does not mean that exercise is not important for heart health.
Masseau was joined in this study by Doug Bowles, a professor in the department of biomedical sciences in the MU Dalton Cardiovascular Research Center, and Michael Davis, a professor and associate head of the department of medical pharmacology and physiology in the MU Dalton Cardiovascular Research Center.

The early-stage results of this research are promising. If additional studies, including animal studies, are successful within the next few years, MU officials will request authority from the federal government to begin human trials. After this status has been granted, researchers may conduct human clinical trials with the hope of developing new treatments for heart disease.

This research is an example of the One Health/One Medicine area of Mizzou Advantage. Mizzou Advantage is a program that focuses on four areas of MU strength: food for the future; media of the future; one health/one medicine; and sustainable energy. The goals of Mizzou Advantage are to strengthen existing faculty networks, create new networks and propel Mizzou’s research, instruction and other activities to the next level.

Nathan Hurst | EurekAlert!
Further information:
http://www.missouri.edu

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

Im Focus: Scientists improve forecast of increasing hazard on Ecuadorian volcano

Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, the Italian Space Agency (ASI), and the Instituto Geofisico--Escuela Politecnica Nacional (IGEPN) of Ecuador, showed an increasing volcanic danger on Cotopaxi in Ecuador using a powerful technique known as Interferometric Synthetic Aperture Radar (InSAR).

The Andes region in which Cotopaxi volcano is located is known to contain some of the world's most serious volcanic hazard. A mid- to large-size eruption has...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

New thruster design increases efficiency for future spaceflight

16.08.2017 | Physics and Astronomy

Transporting spin: A graphene and boron nitride heterostructure creates large spin signals

16.08.2017 | Materials Sciences

A new method for the 3-D printing of living tissues

16.08.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>