Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Swedish researchers tracking down early diagnosis of Parkinson’s disease

29.04.2011
In Parkinson’s disease, the human body generates antibodies to combat the amyloid-producing protein alpha synuclein early in the course of the disease. A simple blood test that measures these antibodies can facilitate early diagnosis of the disorder, writes Ludmilla Morozova-Roche and her associates at Umeå University in Sweden in the latest issue of the journal PLoS One.

The need for diagnostic biomarkers for degenerative disorders affecting the nervous system, such as Parkinson’s and Alzheimer’s, is great and acute. Early diagnosis of such diseases would enable treatment at a stage when they are most responsive to intervention, during the period when the greatest number of nerve cells are being damaged or dying. Research is underway around the world to develop substances that can affect the course of the disease.

What many neurodegenerative diseases have in common is that they are caused by proteins that lump together into so-called amyloid. Ludmilla Morozova-Roche’s research team has found endogenous antibodies against the most important amyloid-producing protein in Parkinson’s disease, antibodies that could function as a diagnostic marker for the disease. Monitoring the levels of endogenous antibodies in patients’ blood serum is simple and requires nothing more than a blood sample. This can become a method in clinical practice.

Ludmilla Morozova-Roche’s research is conducted in collaboration with Lars Forsgren, professor of neurology at Umeå University and chief physician at Norrlands University Hospital in Umeå, who is directing the research program on early diagnostics and monitoring of Parkinson’s patients. The findings indicate that autoimmunity may play a protective role in Parkinson’s disease. Immune reactions to the disease’s most significant amyloid-producing protein alpha synuclein may be of value in developing treatment strategies such as vaccination with amyloid antigens and antibodies, especially in the early stages of the disorder.

For more information, please contact Ludmilla Morozova-Roche, professor of medical biophysics at the Department of Medical Chemistry and Biophysics, Umeå University at phone: +46 (0)90-786 52 83 mobile: +46 (0)73-620 52 83

e-mail ludmilla.morozova-roche@medchem.umu.se

Pressofficer Bertil Born; +46-703 886058, bertil.born@adm.umu.se

Reference:
Kiran Yanamandra, Marina A. Gruden, Vida Casaite, Rolandas Meskys, Lars Forsgren, Ludmilla A. Morozova-Roche: α-Synuclein Reactive Antibodies as Diagnostic Biomarkers in Blood Sera of Parkinson's Disease Patients PLoS One, Volume 6, Issue 4, e18513:

Bertil Born | idw
Further information:
http://www.vr.se
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0018513

More articles from Health and Medicine:

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

nachricht High speed video recording precisely measures blood cell velocity
15.11.2017 | ITMO University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>