Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Swedish researchers’ discovery promises unique medicine for treatment of chronic and diabetic wounds

29.05.2012
A unique new medicine that can start and hasten healing of diabetic and other chronic sores is being developed at Umeå University in Sweden. After several years of successful experimental research, it is now ready for clinical testing.

Behind this new medicine is a group of researchers at the Department of Medical Chemistry and Biophysics who have made the unique finding that the protein plasminogen is a regulator that initiates and hastens wound healing by triggering the inflammatory reaction. Their discovery is now being published in the highly ranked journal Blood.

“Today we have the knowledge needed to develop a medicine,” says Professor Tor Ny, one of the authors of the article. “The bulk of the preclinical research has been completed, and we have been in contact with the Medical Products Agency to discuss a program for clinical testing.”

Plasminogen is a well-known plasma protein that is produced in the liver and found in all bodily fluids. The Umeå researchers have re-evaluated its role and managed to show that the concentration of plasminogen increases dramatically in and around wounds, which is an important signal to start the inflammatory reaction required for healing. In diabetic sores the level of plasminogen does not rise in the same way, and this seems to be the reason why these sores do not heal. In mice and rats the researchers were able to show that the healing process starts immediately when plasminogen is injected into the sore, which then heals fully.

A cell line for producing plasminogen on a larger scale has also been developed, and the goal is to be able to start clinical testing as soon as funding can be arranged. The researchers have high hopes, as plasminogen is an endogenous substance that can be assumed not to produce side effects.

The need for a biological pharmaceutical for treating intractable wounds is pressing indeed. Diabetic sores that heal poorly or not at all are the most severe type of chronic sores, affecting millions of people annually. Many of the roughly 350 million diabetes patients in the world develop foot ulcers, and in 10-15 million cases this ultimately leads to amputation. Today’s treatment of diabetic ulcers consists primarily of traditional wound care, with compresses and bandages; there is no effective medication.

The Umeå researchers are initially concentrating on diabetic wounds, but the medicine has great potential for working on other types of stubborn sores. This includes damaged eardrums and periodontitis. The new pharmaceutical has moreover been shown to be helpful in combatting antibiotic-resistant bacteria (MRSA).

Reference
Yue Shen, Yongzhi Guo, Peter Mikus, Rima Sulniute, Malgorzata Wilczynska, Tor Ny, Jinan Li: Plasminogen is a key proinflammatory regulator that accelerates the healing of acute and diabetic wounds Blood. 2012 May 4. [Epub ahead of print]

For more information, please contact Professor Tor Ny: mobile: +46 (0)73-620 50 65; e-mail tor.ny@medchem.umu.se

Hans Fällman | idw
Further information:
http://www.umu.se
http://www.vr.se

More articles from Health and Medicine:

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Research reveals how order first appears in liquid crystals

23.05.2018 | Life Sciences

Space-like gravity weakens biochemical signals in muscle formation

23.05.2018 | Life Sciences

NIST puts the optical microscope under the microscope to achieve atomic accuracy

23.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>