Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Sun Exposure and Cutaneous HPV Infection Found Synergistic in Skin Cancers, Moffitt Cancer Center Researchers Say

Add HPV infection to skin cancer risks of light skin color, male sex, age
Researchers at Moffitt Cancer Center and colleagues at the University of South Florida and the German Cancer Research Center in Heidelberg have found that having antibodies for cutaneous types of human papillomavirus (HPV), coupled with sun exposure (ultraviolet radiation) or poor tanning ability, can act "synergistically" in the development of non-melanoma skin cancers such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).

A number of studies into the relationship between cutaneous HPV and sun exposure have been conducted previously but with mixed results, the researchers said.

This study, the first to investigate interaction effects between genus-specific cutaneous HPV positivity and multiple measures of sunlight exposure as related to BCC and SCC in a U.S. population, was published in a recent issue of The Journal of Infectious Diseases.

"UV radiation exposure is the most important risk factor for the development of non-melanoma skins cancer," said study lead author Dana E. Rollison, Ph.D., Moffitt associate member, vice president and chief health information officer. "Cases of non-melanoma skin cancers are increasing despite the increased use of sunscreen products. Thus, so that new interventions can be developed, there is a need to identify co-factors that may interact with UV radiation exposure in increasing the skin cancer risk."

According to the authors, the risk factors for basal cell and squamous cell carcinomas are male sex; age; light skin, eyes and hair; and UV radiation exposure.

UV radiation exposure and light skin pigmentation are the most recognized risk factors. People with low melanin production tend to have difficulty tanning when exposed to UV radiation.

Skin pigmentation, created by chemical melanin production in the skin, is the "main photoprotective mechanism in the skin," noted the researchers.

The researchers hypothesized that persistent HPV infection may promote tumor progression by interfering with an individual's response to UV radiation-induced DNA damage and that HPV plays a synergistic role in the development of BCC and SCC. Accordingly, their goal was to investigate the potential "modifying effects of cutaneous HPV seroreactivity on the associations between sunlight exposure, host susceptibility to UV radiation exposure, and both BCC and SCC."

The study recruited 204 patient volunteers with BCC, 156 with SCC, and 297 controls with no reported cancer types. The three groups were surveyed on demographics, personal constitutional characteristics, lifestyle factors and measurements of sunlight exposure. Each volunteer provided a blood sample for cutaneous HPV antibody measurement.

"Sun-related factors were associated with BCC and SCC," Rollison said. "Cutaneous sensitivity to sunlight exposure - specifically experiencing a blistering sunburn - and poor tanning ability were associated with a higher prevalence of antibodies to cutaneous HPV types in genus beta. The associations between poor tanning ability and SCC were significantly greater among those positive for antibodies to cutaneous HPV types in genera alpha and beta."

Additional studies are needed, including those measuring infection with cutaneous HPV types in multiple genera, concluded the researchers.

"Identifying how HPV infections might influence sunlight-associated risks of NMSC may lead to improved identification of high-risk individuals and also aid in the development of new prevention strategies," Rollison said.

Their research was supported by a grant from Florida's James & Esther King Biomedical Research Program (06NIR-08).

About Moffitt Cancer Center
Follow Moffitt on Facebook:
Follow Moffitt on Twitter: @MoffittNews
Follow Moffitt on YouTube: MoffittNews

Located in Tampa, Moffitt Cancer Center is a National Cancer Institute-designated Comprehensive Cancer Center, which recognizes Moffitt's excellence in research and contributions to clinical trials, prevention and cancer control. Moffitt is also a member of the National Comprehensive Cancer Network, a prestigious alliance of the country's leading cancer centers, and is listed in U.S. News & World Report as one of "America's Best Hospitals" for cancer.

Media release by Florida Science Communications

Patty Kim | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>