Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Sun-damaged skin responds well to laser treatment

21.10.2008
Researchers at the University of Michigan Health System Department of Dermatology have found scientific evidence that the appearance of sun-damaged skin may be improved by treatment with a topical product that increases the skin's sensitivity to light, followed by laser therapy.

In the new study, participants whose skin was sun-damaged – or photodamaged – were treated with a topical photosensitizer called 5-aminolevulinic acid (5-ALA) and then with a pulsed dye laser. This type of treatment, known as photodynamic therapy, increased collagen levels in the skin and also produced other skin changes that are known to improve its appearance.

The results also suggest that skin with the worst sun damage may respond particularly well to this treatment.

"This is new scientific evidence that photodynamic therapy may in fact be a useful tool to improve the appearance of the skin. This type of therapy has been performed in clinical practice for the past few years, but we've never had detailed molecular evidence for why it may work," says lead author Jeffrey S. Orringer, M.D., associate professor of dermatology at the U-M Health System and director of U-M's Cosmetic Dermatology and Laser Center. The study appears in the October issue of the Archives of Dermatology.

The study looked at 24 adults, ages 54 to 83, all of whom had significant photodamage on the forearm skin. They received a three-hour application of 5-ALA followed by pulsed dye laser therapy. Researchers examined biopsies taken before and at several times after the treatments, and they recorded the molecular changes in the participants' skin at various stages.

Among many other molecular changes, levels of the proteins procollagen I and procollagen III increased after treatment. For instance, one month after treatment, levels of procollagen I peaked with an increase of 2.65 times the pre-treatment levels. Procollagen III peaked one month after treatment with an increase of 3.32 times the pre-treatment levels. Other protein levels molecular markers also increased.

The study represents the latest example of U-M's human appearance research program's unraveling of the mechanisms by which popular treatments improve the appearance of the skin, Orringer notes.

The group has studied the treatment of sun-damaged skin with estrogen, the science behind wrinkle treatments, the effects of smoking on aging skin, and more.

Photodynamic therapy has been used as a treatment for precancerous lesions called actinic keratoses and for some types of skin cancer, but little scientific research has been conducted about its use in appearance-oriented dermatology.

Future studies are needed to gauge whether the improvements shown in the forearm skin in this study can be replicated on facial skin.

Katie Vloet | EurekAlert!
Further information:
http://www.umich.edu

More articles from Health and Medicine:

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Building a brain, cell by cell: Researchers make a mini neuron network (of two)

23.05.2018 | Life Sciences

One-way roads for spin currents

23.05.2018 | Physics and Astronomy

A simple mechanism could have been decisive for the development of life

23.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>