Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Sun-damaged skin responds well to laser treatment

21.10.2008
Researchers at the University of Michigan Health System Department of Dermatology have found scientific evidence that the appearance of sun-damaged skin may be improved by treatment with a topical product that increases the skin's sensitivity to light, followed by laser therapy.

In the new study, participants whose skin was sun-damaged – or photodamaged – were treated with a topical photosensitizer called 5-aminolevulinic acid (5-ALA) and then with a pulsed dye laser. This type of treatment, known as photodynamic therapy, increased collagen levels in the skin and also produced other skin changes that are known to improve its appearance.

The results also suggest that skin with the worst sun damage may respond particularly well to this treatment.

"This is new scientific evidence that photodynamic therapy may in fact be a useful tool to improve the appearance of the skin. This type of therapy has been performed in clinical practice for the past few years, but we've never had detailed molecular evidence for why it may work," says lead author Jeffrey S. Orringer, M.D., associate professor of dermatology at the U-M Health System and director of U-M's Cosmetic Dermatology and Laser Center. The study appears in the October issue of the Archives of Dermatology.

The study looked at 24 adults, ages 54 to 83, all of whom had significant photodamage on the forearm skin. They received a three-hour application of 5-ALA followed by pulsed dye laser therapy. Researchers examined biopsies taken before and at several times after the treatments, and they recorded the molecular changes in the participants' skin at various stages.

Among many other molecular changes, levels of the proteins procollagen I and procollagen III increased after treatment. For instance, one month after treatment, levels of procollagen I peaked with an increase of 2.65 times the pre-treatment levels. Procollagen III peaked one month after treatment with an increase of 3.32 times the pre-treatment levels. Other protein levels molecular markers also increased.

The study represents the latest example of U-M's human appearance research program's unraveling of the mechanisms by which popular treatments improve the appearance of the skin, Orringer notes.

The group has studied the treatment of sun-damaged skin with estrogen, the science behind wrinkle treatments, the effects of smoking on aging skin, and more.

Photodynamic therapy has been used as a treatment for precancerous lesions called actinic keratoses and for some types of skin cancer, but little scientific research has been conducted about its use in appearance-oriented dermatology.

Future studies are needed to gauge whether the improvements shown in the forearm skin in this study can be replicated on facial skin.

Katie Vloet | EurekAlert!
Further information:
http://www.umich.edu

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>