Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study supports possible role of urate in slowing Parkinson's disease progression

14.10.2009
Results confirm those of 2008 study, clinical trial is underway

By examining data from a 20-year-old clinical trial, a research team based at the MassGeneral Institute for Neurodegenerative Diseases (MGH-MIND) and Harvard School of Public Health (HSPH), has found evidence supporting the findings of their 2008 study – that elevated levels of the antioxidant urate may slow the progression of Parkinson's disease.

The report – which will appear in the December 2009 Archives of Neurology and has been released online – analyzed blood and cerebrospinal fluid samples from participants in a 1980s trail of potential Parkinson's medications, confirming the previous study's findings in a totally different group of patients.

"These results were critically important. Only now we can be reasonably sure that the slower rate of progression in patients with higher concentrations of urate is real and not a chance occurrence," says Alberto Ascherio, MD, DrPh, of HSPH, the new study's lead author.

Parkinson's disease – characterized by tremors, rigidity, difficulty walking and other symptoms – is caused by destruction of brain cells that produce the neurotransmitter dopamine. The 2008 study, which investigated the observation that healthy people with elevated but still normal urate levels have a reduced risk of developing Parkinson's, found an association between higher blood urate levels and slower disease progression in 800 participants from a previous clinical trial.

To follow up that finding, the current study reviewed information from a much earlier trial that had investigated whether the drug deprenyl, now an established treatment for Parkinson's, or doses of vitamin E would slow disease progression. The researchers analyzed samples of both blood and cerebrospinal fluid from 800 participants in the DATATOP study, conducted by the Parkinson's Study Group at centers across the U.S. and Canada, to find any association of urate levels with how quickly recently diagnosed patients progressed to the point where they needed to begin standard drug therapy.

Confirming the results of the 2008 study, they found that participants with the highest blood urate levels had a 36 percent less chance of needing to begin treatment during the two-year study period than did those with the lowest urate levels. Similar results were seen for urate levels in the cerebrospinal fluid. Also echoing last year's results, the association of urate levels with risk was robust in men but less clear in women, which may reflect the fact that few women have the high natural urate levels associated with risk reduction.

"Since cerebrospinal fluid circulates in and around the brain, the association with urate CSF levels strengthens the possibility that urate has a protective influence on the cells that degenerate in Parkinson's disease," says Michael Schwarzschild, MD, PhD, of MGH-MIND, the study's senior author. "Urate is a major antioxidant and it can protect brain cells in the lab, which makes this a compelling possibility; but we don't yet know if it's urate itself or some urate-determining factor that helps people with Parkinson's."

One unexpected observation was that the association of urate levels with disease progression was not seen in DATATOP trial participants who had received vitamin E, also a powerful antioxidant that had no effect on disease progression in the original study. The researchers speculate that vitamin E might block urate's effects or that the elevated doses in the DATATOP trial might have had a pro-oxidant effect, possibilities that need further investigation.

With the support of the Michael J. Fox Foundation, Schwarzschild and Ascherio, along with Parkinson Study Group colleagues from across the country, are conducting a multicenter Phase 2 trial at 10 centers. Enrolling 90 recently diagnosed patients, the SURE-PD trial will investigate whether treatment with the urate precursor inosine can safely increase urate levels with a goal of slowing disease progression. More information on this trial is available at http://www.pdtrials.org/en/browse/all/view/259.

"Because elevated urate levels have known health risks, including gout and kidney stones," Schwarzschild stresses, "urate elevation should only be attempted in the context of a closely monitored clinical trial in which potential benefits and risks are carefully balanced."

The current study was supported by grants from the National Institutes of Health, the Department of Defense, the RJG Foundation, the American Federation for Aging Research, the Parkinson Disease Foundation and the Parkinson Study Group. Co-authors of the Archives of Neurology paper are Kui Xu, MD, and Marsha Tennis, RN, MGH-MIND; Wayne Matson, PhD, and Mikhail Bogdanov, PhD, Veterans Administration Medical Center, Bedford, Mass.: Peter LeWitt, MD, Wayne State University School of Medicine, Detroit; Shirley Eberly, MS, Arthur Watts, Karl Keiburtz, MD, Alice Rudolph, PhD, Steven Schwid, MD, David Oakes, PhD, and Ira Shoulson, MD, University of Rochester; M. Flint Beal, MD, Cornell University; Stanley Fahn, MD, Columbia University; Connie Marras, MD, and Anthony Lang, MD, University of Toronto, and Caroline Tanner, MD, PhD, Parkinson's Institute, Sunnyvale, Calif.

Massachusetts General Hospital (www.massgeneral.org), established in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of $550 million and major research centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, systems biology, transplantation biology and photomedicine.

Sue McGreevey | EurekAlert!
Further information:
http://www.massgeneral.org

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>