Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New study suggests link between estrogen exposure, high blood pressure

27.05.2011
While recent studies have shown long-term exposure to estrogen can be a danger to women – overturning physicians’ long-held beliefs that the hormone was good for their patients’ hearts – the process by which estrogen induces high blood pressure was unclear.

In a new study, Michigan State University researchers found long-term estrogen exposure generates excessive levels of the compound superoxide, which causes stress in the body. The buildup of this compound occurs in an area of the brain that is crucial to regulating blood pressure, suggesting that the estrogen-induced buildup causes increased blood pressure.

Findings indicated that the anti-oxidant resveratrol reverses the increase in both superoxide and blood pressure.

The study, led by P.S. MohanKumar, an associate professor of pathobiology and diagnostic investigation in the College of Veterinary Medicine, appears in the American Journal of Physiology – Regulatory, Integrative, and Comparative Physiology. The journal is published by the American Physiological Society.

“This is an important study on at least two levels,” MohanKumar said. “First, it continues to confirm the negative effect that long-term estrogen exposure has for females. Second, it provides a new rationale for how and why this relationship occurs.”

Researchers looked to the rostral ventrolateral medulla, a critical region in the brain stem involved with the maintenance of blood pressure and thought to be associated with hypertension and heart failure.

Believing that chronic exposure of estrogen could influence this area of the brain, they conducted a two-phase experiment using rats, injecting them first with estrogen and then also feeding them the anti-oxidant resveratrol. MohanKumar and his team found chronic exposure caused a significant increase in superoxide in the rostral ventrolateral medulla and in blood pressure. The team also found resveratrol reversed those increases.

“Because so many women use estrogen-only HRT to combat the effects of menopause, it is imperative that we better understand the risks that chronic exposure has for females and why these effects occur,” he said. “In studies such as this, we come one step closer to clarifying the relationship and have established a launch pad for identifying how the process might be interrupted in the future.”

The abstract of the article is available at http://bit.ly/mut5dc, while the full study appears at http://bit.ly/j15YQ1.

In addition to MohanKumar, the study team included MSU researchers Madhan Subramanian, Priya Balasubramanian, Hannah Garver, Carrie Northcutt, Huawei Zhao, Joseph R. Haywood, Gregory D. Fink and Sheba M. J. MonhanKumar.

Michigan State University has been working to advance the common good in uncommon ways for more than 150 years. One of the top research universities in the world, MSU focuses its vast resources on creating solutions to some of the world’s most pressing challenges, while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges.

Jason Cody | EurekAlert!
Further information:
http://www.msu.edu

More articles from Health and Medicine:

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht On track to heal leukaemia
18.01.2017 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

New Study Will Help Find the Best Locations for Thermal Power Stations in Iceland

19.01.2017 | Earth Sciences

Not of Divided Mind

19.01.2017 | Life Sciences

Molecule flash mob

19.01.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>