Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New study suggests link between estrogen exposure, high blood pressure

27.05.2011
While recent studies have shown long-term exposure to estrogen can be a danger to women – overturning physicians’ long-held beliefs that the hormone was good for their patients’ hearts – the process by which estrogen induces high blood pressure was unclear.

In a new study, Michigan State University researchers found long-term estrogen exposure generates excessive levels of the compound superoxide, which causes stress in the body. The buildup of this compound occurs in an area of the brain that is crucial to regulating blood pressure, suggesting that the estrogen-induced buildup causes increased blood pressure.

Findings indicated that the anti-oxidant resveratrol reverses the increase in both superoxide and blood pressure.

The study, led by P.S. MohanKumar, an associate professor of pathobiology and diagnostic investigation in the College of Veterinary Medicine, appears in the American Journal of Physiology – Regulatory, Integrative, and Comparative Physiology. The journal is published by the American Physiological Society.

“This is an important study on at least two levels,” MohanKumar said. “First, it continues to confirm the negative effect that long-term estrogen exposure has for females. Second, it provides a new rationale for how and why this relationship occurs.”

Researchers looked to the rostral ventrolateral medulla, a critical region in the brain stem involved with the maintenance of blood pressure and thought to be associated with hypertension and heart failure.

Believing that chronic exposure of estrogen could influence this area of the brain, they conducted a two-phase experiment using rats, injecting them first with estrogen and then also feeding them the anti-oxidant resveratrol. MohanKumar and his team found chronic exposure caused a significant increase in superoxide in the rostral ventrolateral medulla and in blood pressure. The team also found resveratrol reversed those increases.

“Because so many women use estrogen-only HRT to combat the effects of menopause, it is imperative that we better understand the risks that chronic exposure has for females and why these effects occur,” he said. “In studies such as this, we come one step closer to clarifying the relationship and have established a launch pad for identifying how the process might be interrupted in the future.”

The abstract of the article is available at http://bit.ly/mut5dc, while the full study appears at http://bit.ly/j15YQ1.

In addition to MohanKumar, the study team included MSU researchers Madhan Subramanian, Priya Balasubramanian, Hannah Garver, Carrie Northcutt, Huawei Zhao, Joseph R. Haywood, Gregory D. Fink and Sheba M. J. MonhanKumar.

Michigan State University has been working to advance the common good in uncommon ways for more than 150 years. One of the top research universities in the world, MSU focuses its vast resources on creating solutions to some of the world’s most pressing challenges, while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges.

Jason Cody | EurekAlert!
Further information:
http://www.msu.edu

More articles from Health and Medicine:

nachricht Minimising risks of transplants
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

nachricht FAU researchers demonstrate that an oxygen sensor in the body reduces inflammation
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Stiffness matters

22.02.2018 | Life Sciences

Magnetic field traces gas and dust swirling around supermassive black hole

22.02.2018 | Physics and Astronomy

First evidence of surprising ocean warming around Galápagos corals

22.02.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>