Patients with obstructive sleep apnea often report that they feel like "a new person" after beginning treatment with continuous positive airway pressure therapy. A new study in the Jan. 1 issue of the journal SLEEP provides objective evidence to support these anecdotal reports, showing that three weeks of CPAP therapy significantly reduced fatigue and increased energy in patients with OSA.
Results of the randomized controlled trial show that CPAP therapy significantly reduced self-reported, mean fatigue scores on two independent measures: from 8.76 at baseline to -0.10 post-treatment on the Multidimensional Fatigue Symptom Inventory – Short Form; and from 7.17 at baseline to 4.03 post-treatment on the fatigue-inertia subscale of the Profile of Mood States – Short Form. These results indicate that participants were no longer suffering from clinically significant levels of fatigue after the three-week intervention period.
Self-reported energy levels also increased after three weeks of CPAP therapy, with the mean score on the vigor-activity subscale of the Profile of Mood States – Short Form increasing significantly from 14.28 at baseline to 16.52 post-treatment. Significant changes in fatigue and energy were not observed in participants who received placebo CPAP.
"This was one of the first double-blind studies of the effects of CPAP on fatigue," said lead author Lianne Tomfohr, graduate research assistant in the joint doctoral program at San Diego State University and the University of California, San Diego. "These results are important, as they highlight that patients who comply with CPAP therapy can find relief from fatigue and experience increases in energy and vigor after a relatively short treatment period."
Further analysis found that CPAP appeared to be especially beneficial for participants who were excessively fatigued or sleepy before treatment. CPAP therapy significantly reduced self-reported daytime sleepiness in this group, with their mean score on the Epworth Sleepiness Scale dropping from 13.0 at baseline to 8.9 post-treatment.
According to the American Academy of Sleep Medicine, OSA is a common sleep-related breathing disorder that affects at least two to four percent of the adult population. OSA occurs when the muscles relax during sleep, causing soft tissue in the back of the throat to collapse and block the upper airway. Most people with OSA snore loudly and frequently, and they often experience fatigue and excessive daytime sleepiness.
The treatment of choice for OSA is CPAP therapy, which provides a steady stream of air through a mask that is worn during sleep. This airflow keeps the airway open to prevent pauses in breathing and restore normal oxygen levels.
Tomfohr and a team of UCSD researchers studied 59 adults with a mean age of 48 years. Overnight polysomnography in a sleep lab confirmed that each participant had OSA, which was defined as having an apnea-hypopnea index (AHI) of 10 or more partial reductions (hypopneas) and complete pauses (apneas) in breathing per hour of sleep.
Participants were randomly assigned to receive either therapeutic CPAP or placebo CPAP, and they returned to the sleep lab for a night of either CPAP titration or mock titration. Participants were trained on the use of the equipment and instructed to use it at home each night for three weeks. Questionnaire data were obtained prior to study randomization and after the three-week intervention period.
According to the authors, the mechanisms that underlie the observed changes in fatigue are unclear. They speculate that CPAP may impact fatigue in patients with OSA by reducing inflammation, noting that increases in inflammatory markers in OSA patients have been related to elevated fatigue.
The study was supported by the National Institutes of Health through the National Heart, Lung, and Blood Institute; National Institute on Aging; and National Center for Research Resources.
Help for people who have OSA is available at more than 2,000 AASM-accredited sleep disorders centers across the U.S. More information about CPAP is available from the American Academy of Sleep Medicine at http://www.sleepeducation.com/CPAPCentral/.
The monthly peer-reviewed, scientific journal SLEEP is published online by the Associated Professional Sleep Societies LLC, a joint venture of the American Academy of Sleep Medicine and the Sleep Research Society. The AASM is a professional membership society that is the leader in setting standards and promoting excellence in sleep medicine health care, education and research.
For a copy of the study, "Effects of continuous positive airway pressure on fatigue and sleepiness in patients with obstructive sleep apnea: data from a randomized controlled trial," or to arrange an interview with an AASM spokesperson, please contact Public Relations Coordinator Emilee McStay at 630-737-9700, ext. 9345, or email@example.com.
Emilee McStay | EurekAlert!
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
24.05.2017 | Physics and Astronomy
24.05.2017 | Physics and Astronomy
24.05.2017 | Event News