Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study Shows BPA Exposure in Fetal Livers

05.12.2012
New research from the University of Michigan School of Public Health found BPA, or bisphenol A, in fetal liver tissue, demonstrating that there is considerable exposure to the chemical during pregnancy.

Researchers also found a proportionately higher concentration of free BPA—as opposed to the conjugated forms modified by the body for elimination—further showing that in fetuses the ability to eliminate the chemical from the body is not the same as in adults.

"The general message from our research is that people have to be cognizant of the fact that the adult body may be able to deal with a particular exposure but a developing fetus may not," said Muna Nahar, doctoral student in the School of Public Health's Department of Environmental Health Sciences and first author on the paper.

Previous animal studies have associated BPA with breast and prostate cancer, and reproductive and behavioral abnormalities. Some research on effects to human health has tied BPA to cardiovascular disease, miscarriage, decreased semen quality and childhood behavioral issues. The chemical also may impact metabolism, diabetes and obesity, although more studies are required to determine its effects.

Prior research on BPA—a chemical used in many consumer products, including plastic bottles and metal food and beverage cans—has measured concentrations of the chemical in urine. About 95 percent of those who have been tested in a nationally representative health survey study show some level of BPA, but the research to date had yet to firmly establish the presence of the chemical in tissues.

Understanding the internal dose is essential to determine adverse effects on health, the researchers say. BPA can reach the body through ingestion, inhalation and by contact with the skin.

Nahar and colleagues Dana Dolinoy of the U-M School of Public Health and Chunyang Liao and Kurunthachalam Kannan of the Wadsworth Center at the New York State Department of Health studied the livers of 50 first- and second-trimester fetuses, using high-performance liquid chromatography and mass spectrometry. They found wide variances in how much BPA was present in livers, with some fetuses showing high levels of exposure.

"The finding of free BPA in fetuses is significant," said Dana Dolinoy, the John G. Searle Assistant Professor of Environmental Health Sciences and senior/corresponding author of the study.

After measuring a three-times-higher concentration of free BPA than the conjugated forms in the fetal livers, the researchers then examined the enzymes responsible for metabolizing the chemical and compared them with those at work in adult male and female livers.

"Our research shows that the argument that it's so rapidly metabolized is not true in fetuses," Dolinoy said.

The study appears online in the Journal of Biochemical and Molecular Toxicology, which in early 2013 will publish a special print issue focusing on the National Institute of Environmental Health Sciences Outstanding New Environmental Scientist Award (ONES) projects. Dolinoy was awarded a five-year ONES grant in 2009 for the project titled "In Utero Exposure to Bisphenol A: Effects on the Fetal Epigenome."

Dana Dolinoy: www.sph.umich.edu/iscr/faculty/profile.cfm?uniqname=ddolinoy

Muna Nahar: http://research.sph.umich.edu/person.cfm?deptID=2&groupID=32&ownerID=478

School of Public Health: www.sph.umich.edu/index.html

View a Risk Bites video that explains BPA: http://youtu.be/219JRH3dEwg
(Risk Bites are short insights into the science of risk, produced by Andrew Maynard at the U-M Risk Science Center.)

Laurel Thomas Gnagey | Newswise
Further information:
http://www.umich.edu

More articles from Health and Medicine:

nachricht Fiber optic biosensor-integrated microfluidic chip to detect glucose levels
29.04.2016 | The Optical Society

nachricht Got good fat?
27.04.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nuclear Pores Captured on Film

Using an ultra fast-scanning atomic force microscope, a team of researchers from the University of Basel has filmed “living” nuclear pore complexes at work for the first time. Nuclear pores are molecular machines that control the traffic entering or exiting the cell nucleus. In their article published in Nature Nanotechnology, the researchers explain how the passage of unwanted molecules is prevented by rapidly moving molecular “tentacles” inside the pore.

Using high-speed AFM, Roderick Lim, Argovia Professor at the Biozentrum and the Swiss Nanoscience Institute of the University of Basel, has not only directly...

Im Focus: 2+1 is Not Always 3 - In the microworld unity is not always strength

If a person pushes a broken-down car alone, there is a certain effect. If another person helps, the result is the sum of their efforts. If two micro-particles are pushing another microparticle, however, the resulting effect may not necessarily be the sum their efforts. A recent study published in Nature Communications, measured this odd effect that scientists call “many body.”

In the microscopic world, where the modern miniaturized machines at the new frontiers of technology operate, as long as we are in the presence of two...

Im Focus: Tiny microbots that can clean up water

Researchers from the Max Planck Institute Stuttgart have developed self-propelled tiny ‘microbots’ that can remove lead or organic pollution from contaminated water.

Working with colleagues in Barcelona and Singapore, Samuel Sánchez’s group used graphene oxide to make their microscale motors, which are able to adsorb lead...

Im Focus: ORNL researchers discover new state of water molecule

Neutron scattering and computational modeling have revealed unique and unexpected behavior of water molecules under extreme confinement that is unmatched by any known gas, liquid or solid states.

In a paper published in Physical Review Letters, researchers at the Department of Energy's Oak Ridge National Laboratory describe a new tunneling state of...

Im Focus: Bionic Lightweight Design researchers of the Alfred Wegener Institute at Hannover Messe 2016

Honeycomb structures as the basic building block for industrial applications presented using holo pyramid

Researchers of the Alfred Wegener Institute (AWI) will introduce their latest developments in the field of bionic lightweight design at Hannover Messe from 25...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

The “AC21 International Forum 2016” is About to Begin

27.04.2016 | Event News

Soft switching combines efficiency and improved electro-magnetic compatibility

15.04.2016 | Event News

Grid-Supportive Buildings Give Boost to Renewable Energy Integration

12.04.2016 | Event News

 
Latest News

Quantum Logical Operations Realized with Single Photons

03.05.2016 | Physics and Astronomy

Discovery of a fundamental limit to the evolution of the genetic code

03.05.2016 | Life Sciences

Cavitation aggressive intensity greatly enhanced using pressure at bubble collapse region

03.05.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>