Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study Reveals No Impact of Age on Outcome in Chronic Myeloid Leukemia Patients Treated With Imatinib

31.03.2011
While the median age at diagnosis for chronic myeloid leukemia (CML) is over 60 years old and incidence increases dramatically with age,limited data are available about the long-term outcome for older patients treated with imatinib, the standard first-line therapy used to treat CML.

Results from a study published today in Blood, the Journal of the American Society of Hematology, reveal that age does not affect response to imatinib and study investigators conclude that overall survival for CML is similar in older and younger patients treated with the drug.

Two widely used prognostic scores for CML, the Sokal and EURO risk scores, have historically identified older age as a predicting factor of lower response rate and poorer outcome. However, these risk scores were validated before imatinib was introduced as a therapy for CML and may now hold less relevance, as imatinib has dramatically improved the prognosis for CML patients.

“Older age has typically been considered a poor prognostic factor in patients with CML and has a negative impact on response rates and long-term survival, regardless of treatment,” said Gabriele Gugliotta, MD, co-author of the study and Fellow in the Department of Hematology and Oncology at St. Orsola-Malpighi Hospital at the University of Bologna in Bologna, Italy. “Our study focused on disease progression, treatment response, and survival of this specific patient population to assess the role of imatinib in older patients.”

To test whether age at diagnosis is a valid predictor of response, researchers from several institutions in Italy conducted an analysis of 559 patients with early chronic phase CML (six months or less from diagnosis to start of imatinib treatment) who were enrolled in three concurrent clinical trials in the Gruppo Italiano Malattie Ematologiche dell'Adulto CML Working Party, between May 2003 and April 2007. Trial participants over age 65 were defined as “older” patients and those under age 65 were classified as “younger” patients.

Results from the patient analysis revealed that complete hematologic response, or a return to normal blood cell and platelet counts, was observed at three-month follow-up in 97 percent of the older age group and 96 percent of the younger age group. At six, 12, and 24 months follow-up, 69 percent, 78 percent, and 74 percent of older patients and 67 percent, 77 percent, and 78 percent of younger patients, respectively, achieved complete cytogenetic response, or the point when no leukemic cells are detected in the blood. As for long-term survival, after discounting deaths unrelated to CML in both the older and younger patients, researchers found no significant difference in mortality rates between the two age groups. The adjusted overall survival rate for the older patients was 94 percent, compared to 96 percent for the younger patients (p=0.4), further demonstrating that age was not a significant factor in imatinib response and did not affect patient survival.

“This is the first study that has specifically analyzed the long-term outcome of older patients with early chronic phase CML treated with imatinib,” said Gianantonio Rosti, MD, lead study author and hematologist in the Department of Hematology and Oncology at St. Orsola-Malpighi Hospital at the University of Bologna. “While increasing age is generally associated with higher mortality, the results of our analysis demonstrate that when it comes to treating CML patients, older age must not be a limitation for treatment with imatinib, as it is a very effective therapy for this patient population.”

Reporters who wish to receive a copy of the study or arrange an interview with the authors may contact Claire Gwayi-Chore at 202-776-0544 or cgwayi-chore@hematology.org.

The American Society of Hematology is the world’s largest professional society concerned with the causes and treatment of blood disorders. Its mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology. The official journal of ASH is Blood, the most cited peer-reviewed publication in the field, which is available weekly in print and online.

Lindsey Love | EurekAlert!
Further information:
http://www.hematology.org

More articles from Health and Medicine:

nachricht On track to heal leukaemia
18.01.2017 | Universitätsspital Bern

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

A big nano boost for solar cells

18.01.2017 | Power and Electrical Engineering

Glass's off-kilter harmonies

18.01.2017 | Materials Sciences

Toward a 'smart' patch that automatically delivers insulin when needed

18.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>