Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study links mental illness to early death in people with epilepsy

22.07.2013
People with epilepsy are ten times more likely to die early, before their mid-fifties, compared with the general population, according to a 41 year study in Sweden published today in the Lancet and part-funded by the Wellcome Trust.

The findings reveal a striking correlation between premature death and mental illness in these patients and people with epilepsy were four times more likely to have received a psychiatric diagnosis in their lifetime compared with the general population.

The figures are considerably higher than previously thought and have important implications for epilepsy management.

Researchers at the University of Oxford and Karolinska Institutet studied 69,995 people with epilepsy born in Sweden between 1954 and 2009 and followed up over 41 years, between 1969 and 2009. They compared mortality and cause of death information from these patients with 660,869 age- and sex-matched people from the general population. The study also looked at the unaffected siblings of those with epilepsy, in order to rule out the influence of background factors such as genetic risk factors and upbringing.

Throughout the course of the study, almost nine per cent (6,155) of people with epilepsy died compared with less than one per cent (4,892) of people from the general population.

The most important cause of death in people with epilepsy that was not clearly related to the underlying disease process was death by external causes, such as accident or suicide, accounting for almost 16 per cent of deaths. Three quarters of these deaths were amongst patients who also had a psychiatric diagnosis.

Although suicide and deaths from accidents were still relatively rare, the odds of a person with epilepsy committing suicide during the study were four times higher than the general population and there was a strong correlation with mental illness and substance abuse.

Dr Seena Fazel, a Wellcome Trust Senior Clinical Research Fellow at the University of Oxford and main author of the study, said: "This is the largest report to date to look at psychiatric associations in epilepsy and their contribution to premature mortality. Our finding that three quarters of suicide and accident deaths in epilepsy also had a diagnosis of mental illness strongly identifies this as a high risk population to focus preventative strategies and more intensive treatment.

"Improving the identification, monitoring and treatment of psychiatric problems in epilepsy patients could make an important contribution to reducing the risk of premature death that we're currently seeing in these patients."

The study also reveals that the odds of dying in a non-vehicle accident, such as drug poisoning or drowning, were more than five times higher for people with epilepsy than control populations.

"Our findings also highlight general accidents as a major, preventable cause of death in epilepsy patients and suggest that specific warnings, in addition to those already given around driving, should be provided to patients at the time of diagnosis to ensure they are aware of the risks," added Dr Fazel.

Professor Charles Newton from the Wellcome Trust programme at the Kenyan Medical Research Institute (KEMRI) and the Department of Psychiatry at Oxford University, said: "Although it is well –recognised that psychiatric and addiction disorders occur in epilepsy, in high income (Western) countries, epilepsy is often managed by neurologists only. The findings from this study would suggest that clinical epilepsy services should review their liaison with psychiatric and addiction services as a priority."

This is the first study to look at the odds of premature death in people with epilepsy compared with their unaffected siblings, revealing that they do not differ significantly from odds of death in epilepsy compared with general population controls. This provides further weight to the evidence that epilepsy as a disease is an independent risk factor for death by any cause.

The study was funded by the Wellcome Trust, the Swedish Prison and Probation Service and the Swedish Research Council.

Jen Middleton | EurekAlert!
Further information:
http://www.wellcome.ac.uk

More articles from Health and Medicine:

nachricht Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital

nachricht New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

Im Focus: Virtual Reality for Bacteria

An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications

Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...

Im Focus: A space-time sensor for light-matter interactions

Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.

The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

Blockchain is becoming more important in the energy market

05.12.2017 | Event News

 
Latest News

New research identifies how 3-D printed metals can be both strong and ductile

11.12.2017 | Physics and Astronomy

Scientists channel graphene to understand filtration and ion transport into cells

11.12.2017 | Materials Sciences

What makes corals sick?

11.12.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>