Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Study links mental illness to early death in people with epilepsy

People with epilepsy are ten times more likely to die early, before their mid-fifties, compared with the general population, according to a 41 year study in Sweden published today in the Lancet and part-funded by the Wellcome Trust.

The findings reveal a striking correlation between premature death and mental illness in these patients and people with epilepsy were four times more likely to have received a psychiatric diagnosis in their lifetime compared with the general population.

The figures are considerably higher than previously thought and have important implications for epilepsy management.

Researchers at the University of Oxford and Karolinska Institutet studied 69,995 people with epilepsy born in Sweden between 1954 and 2009 and followed up over 41 years, between 1969 and 2009. They compared mortality and cause of death information from these patients with 660,869 age- and sex-matched people from the general population. The study also looked at the unaffected siblings of those with epilepsy, in order to rule out the influence of background factors such as genetic risk factors and upbringing.

Throughout the course of the study, almost nine per cent (6,155) of people with epilepsy died compared with less than one per cent (4,892) of people from the general population.

The most important cause of death in people with epilepsy that was not clearly related to the underlying disease process was death by external causes, such as accident or suicide, accounting for almost 16 per cent of deaths. Three quarters of these deaths were amongst patients who also had a psychiatric diagnosis.

Although suicide and deaths from accidents were still relatively rare, the odds of a person with epilepsy committing suicide during the study were four times higher than the general population and there was a strong correlation with mental illness and substance abuse.

Dr Seena Fazel, a Wellcome Trust Senior Clinical Research Fellow at the University of Oxford and main author of the study, said: "This is the largest report to date to look at psychiatric associations in epilepsy and their contribution to premature mortality. Our finding that three quarters of suicide and accident deaths in epilepsy also had a diagnosis of mental illness strongly identifies this as a high risk population to focus preventative strategies and more intensive treatment.

"Improving the identification, monitoring and treatment of psychiatric problems in epilepsy patients could make an important contribution to reducing the risk of premature death that we're currently seeing in these patients."

The study also reveals that the odds of dying in a non-vehicle accident, such as drug poisoning or drowning, were more than five times higher for people with epilepsy than control populations.

"Our findings also highlight general accidents as a major, preventable cause of death in epilepsy patients and suggest that specific warnings, in addition to those already given around driving, should be provided to patients at the time of diagnosis to ensure they are aware of the risks," added Dr Fazel.

Professor Charles Newton from the Wellcome Trust programme at the Kenyan Medical Research Institute (KEMRI) and the Department of Psychiatry at Oxford University, said: "Although it is well –recognised that psychiatric and addiction disorders occur in epilepsy, in high income (Western) countries, epilepsy is often managed by neurologists only. The findings from this study would suggest that clinical epilepsy services should review their liaison with psychiatric and addiction services as a priority."

This is the first study to look at the odds of premature death in people with epilepsy compared with their unaffected siblings, revealing that they do not differ significantly from odds of death in epilepsy compared with general population controls. This provides further weight to the evidence that epilepsy as a disease is an independent risk factor for death by any cause.

The study was funded by the Wellcome Trust, the Swedish Prison and Probation Service and the Swedish Research Council.

Jen Middleton | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>