Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study Finds Promising Drug Treatment for Improving Language, Social Function in People with Autism

30.09.2011
Most drug therapy interventions for people with autism have targeted psychiatric problems, including aggression, anxiety and obsessive behavior.

Now, University of Missouri researchers are examining the use of propranolol (a drug used to treat high blood pressure and control heart rate as well as to reduce test anxiety) to improve the primary traits associated with autism – difficulty with normal social skills, language and repetitive behaviors. MU researchers say the drug is a promising new avenue for improving language and social function.

David Beversdorf found that the drug propranolol is beneficial for improving language development and social communication in people with autism.

“We can clearly say that propranolol has the potential to benefit language and may help people with autism function appropriately in social situations, including making eye contact with others,” said David Beversdorf, associate professor and Thompson Endowed Chair at the MU Thompson Center for Autism and Neurodevelopmental Disorders. “Enhancing both language and social function is significant because those are two of the three main features of autism. Clinical trials will assess the drug’s effect on all three features, including repetitive behaviors.”

Propranolol has been used for decades with minimal side effects reported in healthy individuals. The MU researchers are the first to study the benefits of the drug in autism in a controlled manner. The next step is to conduct clinical trials to determine if the benefits are sustained over time and if the benefits outweigh other effects.

Propranolol acts by reducing the effect of norepinephrine brought on by stress in order to allow the brain to function as if there is no stress. This is beneficial for persons who have trouble with test taking. In people with autism, the brain is hardwired in a different way, making processing more rigid in terms of social function and language. The researchers think that the drug acts on these hardwired processes and therefore, improves tasks and functioning in these areas.

“When healthy persons are under stress their neurons fire in an expedited manner, to respond quickly to the stressor, that does not allow input from remote sources,” Beversdorf said. “Unfortunately when trying to solve difficult problems, we need information from remote sources. For example, if we come in contact with a tiger, we are programmed to respond quickly and run away. However, this fight or flight response isn’t as helpful in today’s society because instead of facing a tiger, we are taking an exam or giving a speech. Evidence suggests that individuals with autism have a similar difficulty accessing input from remote sources regardless of the presence of stress when using language and communicating.”

In previous studies, the researchers found that propranolol helped people with autism solve simple anagrams, word unscrambling tasks. It also increased semantic word fluency, which requires understanding the definition of words and connectivity among different brain regions. It did not help with letter fluency, which involves identifying words that start with specific letters and requires less distributed connectivity among brain regions.

“We are interested to see if we can predict who will or will not respond to this drug among those with autism,” Beversdorf said. “In the follow-up study, we’re looking at markers of increased stress reactivity. If we find that those with higher stress reactivity are more sensitive to the effects of propranolol, it might help to identify who will benefit most from the drug.”

Beversdorf is a physician and faculty member at MU in the departments of Radiology, Neurology and Psychological Sciences. The study, “Effect of Propranolol on Word Fluency in Autism,” was published in Cognitive and Behavior Neurology.

Emily Martin | EurekAlert!
Further information:
http://www.missouri.edu

More articles from Health and Medicine:

nachricht Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital

nachricht New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

Im Focus: Virtual Reality for Bacteria

An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications

Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...

Im Focus: A space-time sensor for light-matter interactions

Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.

The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Midwife and signpost for photons

11.12.2017 | Physics and Astronomy

How do megacities impact coastal seas? Searching for evidence in Chinese marginal seas

11.12.2017 | Earth Sciences

PhoxTroT: Optical Interconnect Technologies Revolutionized Data Centers and HPC Systems

11.12.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>