Study findings suggest that cumulative exposure to lead at levels likely to be experienced in community settings may have adverse consequences for women’s cognition in their later years.
The objective of the study was to examine biomarkers of lead exposure in relation to performance on cognitive tests given to older women. Lead exposure is measured in two ways: blood lead level, which is a reading of recent lead dosage, and bone lead level, which is a cumulative measure of lead exposure over many years. For this study, the researchers assessed bone lead levels in the tibia and the patella.
The analysis of all cognitive tests combined showed levels of all three lead biomarkers were associated with worse cognitive performance, with the association between bone lead and letter fluency scoring dramatically different from the other bone lead/cognitive score associations. Although levels of patella and blood lead also were associated with worse cognitive function, results were statistically significant only for tibia lead, which typically reflects longer-ago exposures than patella lead. The pattern of association suggests that lead exposures in the distant past may be more important than relatively recent exposures in influencing cognitive function in older women.
“The identification of modifiable risk factors for cognitive decline may provide important clues for delaying or even preventing dementia,” wrote first author Jennifer Weuve and colleagues.
“Findings in this study are important because of their long-range consequences on the public health of an aging generation,” said EHP editor-in-chief Hugh A. Tilson, PhD. “Impaired cognition and cognitive decline in older women are associated with heightened risks of dementia, physical disability, hospitalization and reduced quality of life in later years.”
Other authors of the paper included Susan A. Korrick, Marc A. Weisskopf, Louise M. Ryan, Joel Schwartz, Huiling Nie, Francine Grodstein and Howard Hu. Support for this research was provided by the National Institute of Environmental Health Sciences, the National Cancer Institute, the National Institute on Aging and the National Institutes of Health.
The article is available free of charge at: http://www.ehponline.org/members/2008/11846/11846.html.EHP is published by the National Institute of Environmental Health Sciences (NIEHS), part of the U.S. Department of Health and Human Services. EHP is an Open Access journal. More information is available online at http://www.ehponline.org/. Brogan & Partners Convergence Marketing handles marketing and public relations for the publication and is responsible for creation and distribution of this press release.
Julie Hayworth-Perman | Newswise Science News
New 3-D imaging reveals how human cell nucleus organizes DNA and chromatin of its genome
28.07.2017 | University of California - San Diego
Malaria Already Endemic in the Mediterranean by the Roman Period
27.07.2017 | Universität Zürich
Spectrally narrow x-ray pulses may be “sharpened” by purely mechanical means. This sounds surprisingly, but a team of theoretical and experimental physicists developed and realized such a method. It is based on fast motions, precisely synchronized with the pulses, of a target interacting with the x-ray light. Thereby, photons are redistributed within the x-ray pulse to the desired spectral region.
A team of theoretical physicists from the MPI for Nuclear Physics (MPIK) in Heidelberg has developed a novel method to intensify the spectrally broad x-ray...
Physicists working with researcher Oriol Romero-Isart devised a new simple scheme to theoretically generate arbitrarily short and focused electromagnetic fields. This new tool could be used for precise sensing and in microscopy.
Microwaves, heat radiation, light and X-radiation are examples for electromagnetic waves. Many applications require to focus the electromagnetic fields to...
Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers
Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...
Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.
At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...
3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects
A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...
26.07.2017 | Event News
21.07.2017 | Event News
19.07.2017 | Event News
28.07.2017 | Health and Medicine
28.07.2017 | Power and Electrical Engineering
28.07.2017 | Life Sciences