Today cancer is a public health disease that statistically afflicts every third Swede some time during their lifetimes. Although certain external factors such as smoking, obesity, and exaggerated sunbathing increase the risk of cancer, everyone can develop this disease, regardless of these factors.
This is because during our lifetime we gather mutations in our genes that govern how the body’s cells grow and multiply. Sometimes these mutations affect important cellular programs, entailing that a cell somewhere in the body receives a growth advantage that makes it grow and multiply until a tumor has been formed.
In his dissertation, Andreas Höglund shows that cancer cells that carry a specific genetic defect are extra susceptible to treatment that damages the cells’ DNA.
“Cancer cells that express the protein Myc at unnaturally high levels are extra sensitive to these types of treatment,” says Andreas Höglund.
Myc is a vital protein in the body that governs the reading of thousands of genes. Myc does not cause cancer until mutations lead to abnormally high levels of this protein, and further defense mechanisms are knocked out. Defective expression of Myc is one of the most common causes of cancer.
In the dissertation studies Andreas Höglund also maps signalling paths that govern the cell’s ability to recognize and repair damaged DNA. In collaboration with pharmacuetical companies, small chemical compounds have been tested in the hope of being able to develop these beyond a preclinical setting. By steering the binding of these compounds to precisely those signal paths that govern the cell’s ability to recognize and repair DNA damage, it was possible to neutralize the cancer cells.
“Directing treatment toward the signal paths we have identified is highly appropriate for cancer cells with high Myc levels. The hope is to be able to use the Myc signature in a number of cancer diseases in order to attain more specific treatment, which also has the potential of reducing side effects in comparison with current treatment methods,” says Andreas Höglund.
Andreas Höglund was born and raised in Härnösand, where he majored in science in high school, graduating in 1999. In 2001 he started the master’s program in biotechnology at Umeå University, finishing in 2006.About the public defense
The external examiner is Professor Thomas Helleday, Department of Genetics, Microbiology, and Toxicology, Stockholm University, Stockholm, Sweden and Gray Institute for Radiation and Biology, Oxford University, UK.For further information, please contact:
Ingrid Söderbergh | idw
3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg
Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
23.05.2018 | Life Sciences
23.05.2018 | Physics and Astronomy
23.05.2018 | Life Sciences