A team of researchers led by Dr. Jon Matsumura, head of the vascular surgery division at University of Wisconsin School of Medicine and Public Health, found the clinical trial PROTECT (Carotid Artery Stenting with Distal Embolic Protection with Improved System) had the lowest rate of complications ever in patients considered high risk for carotid endarterectomy (CEA)—the gold standard for opening a blocked carotid artery. Carotid artery stenosis, or the narrowing of blood vessels in the neck, is one of the leading causes of strokes in the United States.
"Recent improvements in devices designed specifically for carotid artery stenting have resulted in safer procedures and better clinical outcomes," says Matsumura. "These technological advances, combined with a stronger understanding of patient risk factors, have also improved our ability to select which patients are best suited for the less invasive procedure."
The PROTECT study was a prospective, multi-center clinical trial designed to examine the safety of Emboshield Pro—an embolic protection device used in combination with stenting to help enlarge the blocked artery and capture any plaque that could dislodge during the process. The device is manufactured by Abbott Vascular, which also funded the research. Findings were peer-reviewed before publication.
The study enrolled a total of 322 patients with carotid artery stenosis at 38 centers across the United States between 2006 and 2008. The first 220 patients received a stent and Emboshield Pro, while the other 102 received a stent and an older, now obsolete embolic protection device called Emboshield BareWire. Researchers tracked the composite of clinical outcomes, including death, stroke or myocardial infarction (DSMI) up to 30-days post procedure. Of the 220 who were treated with Emboshield Pro, three patients had a minor stroke (1.4 %), one had a major stroke (0.5%), and one had a myocardial infarction (0.5%), for an overall DSMI rate of 2.3 percent, the lowest rate of complications ever recorded for the procedure in similar multicenter high-risk patient populations.
"These results are consistent with the trends from other trials, where we are seeing complication rates dropping for patients being treated with stents and embolic protection devices," Matsumura says. "This is very good news for high-risk patients suffering with carotid artery disease, who only a decade ago had limited treatment options and poor long-term outcomes."
The US Food and Drug Administration approved carotid artery stenting for high-risk surgical patients in 2004, and recently approved it for standard-risk patients in May 2011. The procedure, which is considered less invasive than carotid endarterectomy, involves a catheter being inserted in the femoral artery of the groin and guided via x-ray to the blocked artery in the neck, where a small balloon is inflated to reopen the vessel. Embolic protection devices work in tandem with stents to help support the newly opened artery and to catch any plaque that could break off during the process and cause a stroke. Strokes affect at least 731,000 people a year in the United States alone, with as many as 25 percent of them being caused by carotid artery disease.
University of Wisconsin Hospital and Clinics is a regional training center for physicians from around the Midwest to learn how to perform advanced endovascular procedures, such as carotid artery stenting. Matsumura is currently running numerous clinical trials to help further determine the safety of stenting in lower-risk patient populations.
Co-authors of the study include Dr. William Gray, NewYork–Presbyterian/Columbia University Medical Center; Seemant Chaturvedi, Wayne State University; Dr. Dai Yamanouchi, University of Wisconsin School of Medicine and Public Health; and Lei Peng and Dr. Patrick Verta, both of Abbott Vascular Endovascular Clinical Science. Copies of the study are available upon request.
Gian Galassi | EurekAlert!
NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University
How to turn white fat brown
07.12.2016 | University of Pennsylvania School of Medicine
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
07.12.2016 | Health and Medicine
07.12.2016 | Life Sciences
07.12.2016 | Health and Medicine