Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New sound recording device helps doctors study link between cough and reflux

28.09.2010
Coughing episodes are closely related to gastroesophageal reflux symptoms in patients who experience chronic cough, irrespective of other diagnoses, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. Gastroesophageal reflux occurs when the acid contents of the stomach back up, or reflux, into the esophagus. This typically produces heartburn, a burning sensation below the sternum where your ribs come together.

"This is the first study to investigate the temporal relationship between cough and reflux events using a validated sound recording device to register the precise timing and occurrence of actual cough sounds," said Jaclyn A. Smith, PhD, MRCP, of the University of Manchester and lead author of the study. "By using this novel approach, which helps prevent under-reporting of coughing occurrences, we are better able to identify how cough events and reflux events are linked to one another." Watch Dr. Smith discuss her study at http://www.youtube.com/watch?v=snrbfc7_iag.

Cough — regardless of cause and duration — is the most common symptom for which patients seek medical attention. Chronic cough (i.e., persists for more than eight weeks) is estimated to affect 11 percent to 20 percent of the population, has a high socioeconomic impact and results in significant reduction in quality of life. Proposed causes of chronic cough include gastroesophageal reflux, rhino-sinusitis and asthma, although recent studies suggest that targeting such mechanisms with drugs only results in approximately half of patients reporting symptom relief.

The majority of studies assessing reflux-cough associations have used a data logger and/or symptom diary to record coughs, which has been shown to significantly under-report the occurrence of coughing. However, in this study, novel ambulatory cough sound recordings, which allowed patients to continue with their normal routines, together with simultaneous impedance/pH monitoring (i.e., preferable technology for establishing symptom-reflux association) over 24 hours, was carried out in 71 patients with chronic cough, aged 51 to 64 years. The recordings were performed using a custom-built validated recording device and microphone; cough was manually counted using software with an audiovisual display. In addition, all patients underwent cough reflex sensitivity testing to citric acid, and 66 patients underwent gastroscopy.

The study researchers found that 70 percent of patients exhibited temporal associations, with 48 percent having a positive symptom association probability for cough preceded by reflux; 56 percent had a positive symptom association probability for reflux preceded by cough; and 32 percent had both.

The presence of cough preceding reflux points to the possible existence of a self-perpetuating cycle maintaining chronic cough. These results may partly explain the poor efficacy of traditional drugs, such as those targeting gastric acidity in the treatment of chronic cough.

To learn more about gastroesophageal reflux disease, visit the patient center on the AGA Web site at http://www.gastro.org/patient-center.

About the AGA Institute

The American Gastroenterological Association is the trusted voice of the GI community. Founded in 1897, the AGA has grown to include 17,000 members from around the globe who are involved in all aspects of the science, practice and advancement of gastroenterology. The AGA Institute administers the practice, research and educational programs of the organization. www.gastro.org.

About Gastroenterology

Gastroenterology, the official journal of the AGA Institute, is the most prominent scientific journal in the specialty and is in the top 1 percent of indexed medical journals internationally. The journal publishes clinical and basic science studies of all aspects of the digestive system, including the liver and pancreas, as well as nutrition. The journal is abstracted and indexed in Biological Abstracts, CABS, Chemical Abstracts, Current Contents, Excerpta Medica, Index Medicus, Nutrition Abstracts and Science Citation Index. For more information, visit www.gastrojournal.org.

Become an AGA fan on Facebook.

Join our LinkedIn group.

Follow us on Twitter @AmerGastroAssn.

Check out our videos on YouTube.

Alissa J. Cruz | EurekAlert!
Further information:
http://www.gastro.org

More articles from Health and Medicine:

nachricht New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University

nachricht Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Underwater acoustic localization of marine mammals and vehicles

23.11.2017 | Information Technology

Enhancing the quantum sensing capabilities of diamond

23.11.2017 | Physics and Astronomy

Meadows beat out shrubs when it comes to storing carbon

23.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>