"This is the first study to investigate the temporal relationship between cough and reflux events using a validated sound recording device to register the precise timing and occurrence of actual cough sounds," said Jaclyn A. Smith, PhD, MRCP, of the University of Manchester and lead author of the study. "By using this novel approach, which helps prevent under-reporting of coughing occurrences, we are better able to identify how cough events and reflux events are linked to one another." Watch Dr. Smith discuss her study at http://www.youtube.com/watch?v=snrbfc7_iag.
Cough — regardless of cause and duration — is the most common symptom for which patients seek medical attention. Chronic cough (i.e., persists for more than eight weeks) is estimated to affect 11 percent to 20 percent of the population, has a high socioeconomic impact and results in significant reduction in quality of life. Proposed causes of chronic cough include gastroesophageal reflux, rhino-sinusitis and asthma, although recent studies suggest that targeting such mechanisms with drugs only results in approximately half of patients reporting symptom relief.
The majority of studies assessing reflux-cough associations have used a data logger and/or symptom diary to record coughs, which has been shown to significantly under-report the occurrence of coughing. However, in this study, novel ambulatory cough sound recordings, which allowed patients to continue with their normal routines, together with simultaneous impedance/pH monitoring (i.e., preferable technology for establishing symptom-reflux association) over 24 hours, was carried out in 71 patients with chronic cough, aged 51 to 64 years. The recordings were performed using a custom-built validated recording device and microphone; cough was manually counted using software with an audiovisual display. In addition, all patients underwent cough reflex sensitivity testing to citric acid, and 66 patients underwent gastroscopy.
The study researchers found that 70 percent of patients exhibited temporal associations, with 48 percent having a positive symptom association probability for cough preceded by reflux; 56 percent had a positive symptom association probability for reflux preceded by cough; and 32 percent had both.
The presence of cough preceding reflux points to the possible existence of a self-perpetuating cycle maintaining chronic cough. These results may partly explain the poor efficacy of traditional drugs, such as those targeting gastric acidity in the treatment of chronic cough.
To learn more about gastroesophageal reflux disease, visit the patient center on the AGA Web site at http://www.gastro.org/patient-center.
About the AGA Institute
The American Gastroenterological Association is the trusted voice of the GI community. Founded in 1897, the AGA has grown to include 17,000 members from around the globe who are involved in all aspects of the science, practice and advancement of gastroenterology. The AGA Institute administers the practice, research and educational programs of the organization. www.gastro.org.
Gastroenterology, the official journal of the AGA Institute, is the most prominent scientific journal in the specialty and is in the top 1 percent of indexed medical journals internationally. The journal publishes clinical and basic science studies of all aspects of the digestive system, including the liver and pancreas, as well as nutrition. The journal is abstracted and indexed in Biological Abstracts, CABS, Chemical Abstracts, Current Contents, Excerpta Medica, Index Medicus, Nutrition Abstracts and Science Citation Index. For more information, visit www.gastrojournal.org.
Become an AGA fan on Facebook.
Join our LinkedIn group.
Follow us on Twitter @AmerGastroAssn.
Check out our videos on YouTube.
Alissa J. Cruz | EurekAlert!
A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital
Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
25.04.2017 | Physics and Astronomy
25.04.2017 | Materials Sciences
25.04.2017 | Life Sciences