"There is a disparity in the biological aggressiveness of breast cancer," said Garth H. Rauscher, Ph.D., associate professor of epidemiology at the University of Illinois at Chicago. "We tend to think about biological differences being due to differences in genes, but tumor biology can be affected by social or behavioral factors that are associated with socioeconomic status. Our study highlights the importance of the social environment in influencing tumor biology and ultimately influencing disparities."
Rauscher and colleagues examined data from a population-based sample of 989 patients with a recent diagnosis of breast cancer (397 non-Hispanic whites, 411 non-Hispanic blacks and 181 Hispanics) from the Breast Cancer Care in Chicago Study. Patients were aged 30 to 79 years and had primary in situ or invasive breast cancer. A total of 742 patients consented to medical record abstraction and had medical record data available for estrogen receptor (ER) and progesterone receptor (PR) status.
Researchers established socioeconomic disadvantage using four measurements: individual income, individual education and two census tract measures of socioeconomic status ¡ª concentrated disadvantage and concentrated affluence.
Compared with 12 percent of non-Hispanic white patients, 29 percent of non-Hispanic black patients and 20 percent of Hispanic patients had ER- and PR-negative tumors. Non-Hispanic black and Hispanic patients were also more likely to have lower income and less education and to reside in more disadvantaged and less affluent neighborhoods. In addition, all four measures of socioeconomic disadvantage used in the study were strongly associated with ER/PR-negative status.
"It was interesting to see that the main finding remained unchanged regardless of the measure of socioeconomic status we used," Rauscher said. "Patient levels of income and education, as well as neighborhood-level measures of socioeconomic status, were each associated with tumor biology. In each instance, lower socioeconomic status was associated with more aggressive breast cancers that lacked these hormone receptors."
The study was funded by the National Institutes of Health Centers for Population Health and Health Disparities.
Follow the AACR on Twitter: @aacr #aacr
Follow the AACR on Facebook: http://www.facebook.com/aacr.org
About the American Association for Cancer Research
Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR membership includes more than 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 17,000 attendees. In addition, the AACR publishes seven peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the scientific partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of team science and individual grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer.
For more information about the AACR, visit www.AACR.org.
Socioeconomic disadvantage predicts more aggressive estrogen/progesterone receptor negative breast cancer and mediates racial and ethnic disparities in breast cancer aggressiveness.. Garth H. Rauscher1, Elizabeth L. Wiley2, Richard T. Campbell1. 1Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL, 2Department of Pathology, University of Illinois at Chicago, Chicago, IL.Purpose: Racial and ethnic disparities in breast cancer stage at diagnosis are often attributed to social and behavioral factors (e.g., socioeconomic disadvantage, cultural beliefs, health care access and utilization). However, few studies have directly examined their potential role in generating a disparity in the biological aggressiveness of tumors. It is well established that Hispanic and non-Hispanic (nH) Black breast cancer patients are more likely than their non-Hispanic White counterparts to be diagnosed with more aggressive tumors that are negative for estrogen and progesterone receptors (ER/PR negative). Tumor aggressiveness disparities are important because they contribute not only to disparities in stage at diagnosis, but also to disparities in prognosis more generally. We sought to investigate whether the disparity in ER/PR negative disease might be transmitted through the socioeconomic environment.
Conclusions: A substantial portion of the racial/ethnic disparity in breast tumor aggressiveness may be transmitted through social influences that impact the biology of the developing tumor, predisposing disadvantaged groups to more aggressive breast cancer. Socioeconomic disadvantage could lead to higher levels of chronic stress, as well as to differences in dietary or hormonal and reproductive histories, any of which might contribute to disparities in tumor biology.
Jeremy Moore | EurekAlert!
Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University
Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
24.02.2017 | Life Sciences
24.02.2017 | Life Sciences
24.02.2017 | Trade Fair News