Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Never-smokers fare far better than smokers after radiation therapy for head and neck cancer

Human papillomavirus may play a role in better outcomes

Patients with head and neck cancer who have never smoked have much better survival rates after radiation therapy than patients with a history of smoking, new research from UC Davis Cancer Center has found.

The study by Allen M. Chen and colleagues in the UC Davis radiation oncology and otolaryngology departments is among the first of its kind to examine prognosis differences based on smoking history in patients with head and neck cancer who are treated with radiation therapy.

The study, published online in American Journal of Clinical Oncology, found that patients with a history of smoking were more likely to die from their disease and more likely to experience a recurrence after radiation therapy than those without a smoking history.

“There is something unique about the biology of head and neck cancers among non-smokers that makes them more amenable to cure by radiation therapy,” said Chen. “These tumors just melt after a few doses of radiation. If we could understand why, there would be important implications for new drugs and treatments.”

Chen suspects one possible explanation for the difference in response to radiation is human papillomavirus (HPV), a sexually transmitted disease that has been highly associated with head and neck cancer in people who have never smoked.

“The most common theory is that these tumors express a characteristic viral antigen on the cell surface that makes the immune system recognize the cancers more readily, which may enhance the effects of radiation,” he said. “Another theory is that patients who have never smoked and who have HPV-related tumors have fewer mutations in key genes that are critical for radiation response.”

Chen compared 70 patients treated at the UC Davis Department of Radiation Oncology with newly diagnosed, non-metastatic squamous cell carcinoma of the mouth and throat who had a history of smoking with 70 patients with similar diagnoses who reported they had never smoked. Patients who continued to smoke during treatment were not included in the study. Subjects were evenly matched based on age, gender, ethnicity, primary tumor site, disease stage and treatment history.

The analysis found that 14 of the 70 never-smokers experienced a recurrence of their disease compared to 26 patients who had a history of smoking. In addition, 82 percent of never-smokers were disease-free after three years compared to 65 percent of patients who had smoked. Also, those who had never smoked had a lower incidence of complications related to treatment than those who had smoked.

Chen said the next step in the research is to identify biological or genetic differences among smokers and never-smokers diagnosed with head and neck cancers and treated with radiation therapy that might account for the differences in prognosis.

“We are in the process of conducting several laboratory experiments designed to better understand why cancers arising from never smokers are so exquisitely radiosensitive,” Chen said.

UC Davis Cancer Center is the only National Cancer Institute- designated center serving the Central Valley and inland Northern California, a region of more than 6 million people. Its top specialists provide compassionate, comprehensive care for more than 9,000 adults and children every year, and offer patients access to more than 150 clinical trials at any given time. Its innovative research program includes more than 280 scientists at UC Davis and Lawrence Livermore National Laboratory. The unique partnership, the first between a major cancer center and national laboratory, has resulted in the discovery of new tools to diagnose and treat cancer. Through the Cancer Care Network, UC Davis is collaborating with a number of hospitals and clinical centers throughout the Central Valley and Northern California regions to offer the latest cancer-care services.

Dorsey Griffith | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Inflammation Triggers Unsustainable Immune Response to Chronic Viral Infection
24.10.2016 | Universität Basel

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Enormous dome in central Andes driven by huge magma body beneath it

25.10.2016 | Earth Sciences

First time-lapse footage of cell activity during limb regeneration

25.10.2016 | Life Sciences

Deep down fracking wells, microbial communities thrive

25.10.2016 | Earth Sciences

More VideoLinks >>>