Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Smart Anticancer "Nanofiber Mesh"

03.07.2013
A MANA research team has developed a new nanofiber mesh which is capable of simultaneously realizing thermotherapy (hyperthermia) and chemotherapy (treatment with anticancer drugs) of tumors. They succeeded in efficiently inducing natural death (apoptosis) of epithelial cancer cells.

Success in Inducing Natural Death of Epithelial Cancer Cells by Simultaneously Realizing Thermotherapy and Chemotherapy


Cancer treatment using the nanofiber mesh with self-heating/anticancer drug release functions.

A research team headed by Dr. Mitsuhiro Ebara, a MANA Scientist of the Biomaterials Unit (Unit Director: Takao Aoyagi) of the International Center for Materials Nanoarchitectonics (Director-General: Masakazu Aono), National Institute for Materials Science (President: Sukekatsu Ushioda) developed a new nanofiber mesh which is capable of simultaneously realizing thermotherapy (hyperthermia) and chemotherapy (treatment with anticancer drugs) of tumors. Using this nanofiber mesh, the team succeeded in efficiently inducing natural death (apoptosis) of epithelial cancer cells.

Squamous cell carcinoma (SCC) is an epithelial malignant tumor, and is found in many tissues. For example, SCC is thought to account for more than 90% of esophageal cancers, more than 80% of the cervical cancers, and more than 30% of lung cancers.

Although surgery, radiation therapy, and chemotherapy are now three main therapeutic methods according to the stages of cancers, in addition to these methods, thermotherapy has also attracted great attention in recent years. This is because it is possible to induce extinction of cancer cells by heat, as cancer cells are relatively susceptible to heat in comparison with normal cells. It has also been found that thermotherapy enhances the effect of anticancer drugs when used in conjunction with chemotherapy. However, when actually applying thermotherapy and administering anticancer drugs, the two independent therapies must be applied separately, and until now, precise control to realize treatment at the same time and same location had been difficult.

In this research, the team led by Dr. Ebara overcame this problem and succeeded in development of a method for simultaneously performing thermotherapy and chemotherapy of epithelial malignant tumors. The team developed a mesh material which is applied directly to the affected part, and is a hybrid material that combines a temperature-responsive polymer, magnetic nanoparticles, and anticancer drugs.
Although magnetic thermotherapy techniques which administer magnetic nanoparticles directly in the body have been developed previously, the difficulty of handling nanoparticles and the concerns regarding the safety of the magnetic nanoparticles themselves are the problems. The developed nanofiber mesh is easy to handle and can also be used in endoscopic surgery, etc. Moreover, because the magnetic particles contained in the fibers exist stably, diffusion in the body is minimized. For this reason, the developed method is considered to offer higher safety in comparison with methods in which magnetic particles are administered directly.

As the nanofiber mesh contains magnetic nanoparticles, which are a self-heating substance, it is possible to heat the fibers by applying an alternating magnetic field. Furthermore, the temperature-responsive polymer contracts in response to the heat generated by the magnetic nanoparticles, enabling release of the anticancer drugs contained in the nanofiber mesh. When the anticancer activity of this fiber was investigated using a human melanoma cell strain, it was found that ON-OFF control of inducement of apoptosis of the cancer cells was possible by applying an alternating magnetic field.
In 21st century, time-space control of the treatment of diseases is required. That is, it should be possible to administer drugs, etc. at an arbitrary timing and location. Because the newly-developed nanofiber mesh enables simultaneous ON-OFF control of heating of the affected part and drug release, simply by applying an external stimulus, it is considered to be a major advance in the development of next-generation therapeutic materials for 21st century medicine.

Journal information
This research achievement had been announced in the online bulletin of the scientific journal "Advanced Functional Materials" on June 14, 2013.

Mikiko Tanifuji | Research asia research news
Further information:
http://www.nims.go.jp/eng/news/press/2013/06/p201306140.html
http://www.researchsea.com

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>