Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Single-fraction radiation therapy as effective as multiple-fraction radiation therapy for palliation of bone metastases

05.08.2014

Standardizing prescribing practices for single-fraction radiation therapy (SFRT) for palliation of bone metastases could lead to cost savings and improvement in patients’ quality of life, according to a study published in the August 1, 2014 edition of the International Journal of Radiation Oncology • Biology • Physics (Red Journal), the official scientific journal of the American Society for Radiation Oncology (ASTRO).

Bone metastases are a common manifestation of distant spread of disease, occurring most frequently with prostate, breast and lung cancers. Of these patients, two-thirds develop bone metastases to the spine, pelvis or extremities. Radiation therapy is an effective form of palliative treatment for bone metastases.

There are more than 25 randomized controlled trials demonstrating that SFRT provides the same amount of pain control as multiple-fraction radiation therapy (MFRT); however, there is low use internationally of SFRT for bone metastases.

“Use of Single- versus Multiple-Fraction Palliative Radiation Therapy for Bone Metastases: Population-Based Analysis of 16,898 Courses in a Canadian Province,” is one of the largest, current studies on the use of SFRT. The study was designed to determine the use of SFRT in British Columbia, a publicly funded health care system where there is no financial incentive for extended fractionation and all radiation therapy is provided by the BC Cancer Agency with no direct cost to patients.

... more about:
»Cancer »Oncology »Radiation »Society »breast »metastases »primary

Patients who received palliative radiation therapy for bone metastases, regardless of the primary cancer site at diagnosis, from 2007 to 2011 were identified using the BC Cancer Agency’s Cancer Agency Information System (CAIS). During the study period, 8,601 patients received 16,898 courses of radiation therapy.

Patients who received re-irradiation for bone metastases were included, and patients who received more than one course of radiation therapy were considered independently for each course (patients could be counted more than once). Radiation therapy fractionation was divided into two categories: SFRT or MFRT. The most common primary disease site was breast (23.4 percent), and the most frequently treated bony metastatic site was the spine (42.2 percent).

SFRT was used to treat bone metastases in 49.2 percent (7,097) of the radiation therapy courses. SFRT was most commonly used to treat bone metastases that originated from hematological (56.6 percent) and prostate (56.1 percent) cancers; the most common bony metastatic sites treated with SFRT were the ribs (83 percent) and extremity (66.4 percent).

There was a significant variation in the use of SFRT by each of the five cancer centers operated by the BC Cancer Agency during the time of the study, with a range of 25.5 percent to 73.4 percent (p<.001). The study found that the overall utilization rate of SFRT in British Columbia is 49.2 percent, a rate consistent with other Canadian and European data that shows SFRT use ranges from 32 percent to 64 percent. SFRT use is much higher, however, than in the United States, where SFRT use ranges from only 3 percent to 13 percent.

“Previous research has shown that single-fraction radiation therapy is equally as effective as longer multiple-fraction courses. Single-fraction radiation therapy offers greater convenience for patients, is associated with fewer side effects and incurs a lower cost. Even a modest change in the frequency of single-fraction radiation therapy use, in Canada and America, could lead to meaningful cost-savings, improved patient convenience and reduced patient side effects, thereby increasing patients’ quality of life,” said Robert A. Olson, MD, MSc, lead author of the study, and the research and clinical trials lead and a radiation oncologist at the BC Cancer Agency Centre for the North. “As a result of discussing our study outcomes among radiation oncologists in British Columbia, we have already seen an increase in the use of single-fraction radiation therapy for bone metastases. We are hopeful that these results will motivate practice change worldwide.”

For a copy of the study manuscript, contact ASTRO’s Press Office. Learn more about the Red Journal.
 

Michelle Kirkwood | Eurek Alert!
Further information:
https://www.astro.org/

Further reports about: Cancer Oncology Radiation Society breast metastases primary

More articles from Health and Medicine:

nachricht Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital

nachricht New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

Im Focus: Virtual Reality for Bacteria

An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications

Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...

Im Focus: A space-time sensor for light-matter interactions

Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.

The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

Blockchain is becoming more important in the energy market

05.12.2017 | Event News

 
Latest News

New research identifies how 3-D printed metals can be both strong and ductile

11.12.2017 | Physics and Astronomy

Scientists channel graphene to understand filtration and ion transport into cells

11.12.2017 | Materials Sciences

What makes corals sick?

11.12.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>