The method, presented in the British Medical Journal, has been clinically tested on over 200 patients at the Karolinska University Hospital in Solna, Stockholm County.
PEG is typically used for patients unable to swallow and eat in the usual way, and used when improvement in the short term is not expected, for example, in case the patient has throat cancer, esophagus cancer or got a stroke. In Sweden there are several thousand PEG operations per year, and surgery is increasing. One problem with surgery is that the risk of infection is high, which at worst can lead to death. To reduce the risk of infection, cefuroxime, a type of liquid antibiotics for use directly in the blood stream is given today, one hour before surgery.
"It is always difficult for the operating doctor to know whether the infection preventive treatment has been given on time, which could stop the whole operation process", says Dr John Blomberg, PhD Student at Karolinska Institutet and Senior Physician at Karolinska University Hospital.
"In some cases, it is impossible to insert a PEG and then the antibiotics have been given unnecessarily. When a PEG operation fails, which occurs in every ten cases, it usually depends on how the internal organs are located in relation to the abdominal wall and stomach", Dr Blomberg continues.
With the new method for protection against infection, which he and his colleagues present in the scientific journal BMJ, the patient is instead given different antibiotic drugs, a combination of sulfamethoxazole and trimethoprim, as a direct solution in PEG-catheter after surgery is completed. This routine in combination with a lighter workload and a smaller drug cost for hospitals makes this new procedure reduce the cost for PEG operations considerably.
The present study has been done on 234 patients between 2005 and 2009, half of whom were treated with cefuroxime and the other half treated with the mixture of sulfamethoxazole and trimethoprim. Of these 14 patients treated with cefuroxime and 10 patients treated with the mixture of sulfamethoxazole and trimethoprim got an infection. Therefore there are several reasons to recommend this new way of giving antibiotics at PEG operations.
"Both methods give equivalent results in terms of reduced risk of infection for the patient. But the new method is much simpler, and at least ten times cheaper", says Dr Blomberg.
The study was financed by the Swedish Research Council and the Swedish Cancer Foundation.Publication:
British Medical Journal, 2 July 2010, doi:10.1136/bmj.c3115.For further information, please contact:
Press Office | EurekAlert!
Tracking movement of immune cells identifies key first steps in inflammatory arthritis
23.01.2017 | Massachusetts General Hospital
Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign
For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.
According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
24.01.2017 | Earth Sciences
24.01.2017 | Life Sciences
24.01.2017 | Physics and Astronomy