Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Significant benefits in non-small-cell lung cancer from customizing erlotinib treatment

15.09.2008
Lung cancer patients whose tumors carry specific genetic mutations can achieve significantly longer survival when treated with targeted therapies such as erlotinib, Spanish researchers report.

Investigators from the Spanish Lung Cancer Group conducted the largest-ever study to examine the benefits of customizing lung cancer treatment based on mutations in the epidermal growth factor receptor (EGFR) gene.

At the 33rd Congress of the European Society for Medical Oncology (ESMO) in Stockholm they report that patients with the mutations survived for almost two years on average when treated with erlotinib.

“For the first time in lung cancer management, doctors are able, by testing EGFR mutations, to identify a subgroup of patients (between 15-22% according to our experience) who can obtain a new survival landmark in advanced non-small-cell lung cancer, with oral EGFR inhibitors like erlotinib,” said Prof. Rafael Rosell, who presented the new data at the meeting.

The Spanish group took tumor biopsies from 2,312 patients with advanced non-small-cell lung cancer and screened them for two common mutations in the gene for epidermal growth factor receptor, which can be a cause of lung cancer.

The two mutations they screened for were a deletion in exon 19 of the receptor’s tyrosine kinase domain, and a mutation in exon 21. Tumors with EGFR mutations are more frequently seen in people who have never smoked and in women.

The group identified 307 patients who carried the EGFR mutations. Each was treated with erlotinib.

Based on data from 193 patients, the mean survival was 22 months, Prof. Rosell reported. For women, the mean survival was 28 months; for men, 17 months. Mean time to progression was 12 months overall, and was longer in women than in men.

The researchers saw a response to treatment in 71% of patients, including 24 patients who experienced a complete response. The probability of response was twice as high in patients aged 61-71 years and in patients with the exon 19 deletion.

“Therefore non-small-cell lung cancers with EGFR mutations display a two-to-three-fold increment in outcome in comparison with non-small-cell lung cancers treated with chemotherapy, in which median survival is 11 months, time-to-progression is 5 months, and response 20-30%,” Prof. Rosell said.

“These results are a new clinical discovery. The impressive survival and response are undeniable. This is a new landmark of treatment in non-small-cell lung cancer, and the first tangible target for customizing treatment with EGFR tyrosine kinase inhibitors.”

Vanessa Pavinato | alfa
Further information:
http://www.esmo.org

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>