The research published in Clinical Cancer Research today found that specific genetic changes in certain cells may cause childhood kidney cancer.
Lead scientist, Dr Chris Jones at The Institute of Cancer Research says:
“This discovery is a significant step forward and our findings will help locate those who are most at risk and hopefully lead to earlier diagnosis and better monitoring for patients.”
The work is the first to study the entire genome (collection of genes that a person has) within these clusters of cells by analysing ‘DNA copy number changes’.
“Around one per cent of children are born with clusters of embryonic cells in their kidneys left over from growing in the womb. One in a hundred of these children may then go on to develop a Wilms tumour. With the information from a study published today, doctors will be able to focus on which of these clusters pose the biggest threat of developing into cancer,” Dr Jones said.
Around 70 children are diagnosed with Wilms tumour in the UK each year, the most common childhood renal cancer, affecting approximately one in every 10,000 children. Wilms Tumour is very treatable and most children can be cured. However, if both kidneys are affected the cure rate is lower and it is more difficult to preserve kidney function.
These higher risk clusters of embryonic kidney cells, are found in 30-40 per cent of infants with Wilms. Where the cancer has spread to both kidneys, these clusters are found in close to 100 per cent of cases.This latest advance comes hot on the heels of a paper published in November by Professor Nazneen Rahman, Professor of Human Genetics, at The Institute of Cancer Research, which showed that 5 per cent of children with Wilms tumour develop the condition because they have defects in growth genes on chromosome 11. Children with the growth gene abnormalities face about a 20 per cent risk of developing Wilms Tumour and it is also more likely for these children to develop cancer in both kidneys.
The study, published in Nature Genetics, involved 437 children with Wilms tumour from ten British childhood cancer centres and 29 families with more than one child with this form of cancer from around the world.
Dr Lesley Walker, director of cancer information at Cancer Research UK, said: “The causes of many types of childhood cancer are still unknown, so this discovery of some of the genetic changes leading to the development of Wilms tumour, is very important. Although most children with Wilms tumour are successfully treated, these results could help doctors to optimise the care they are given. In addition, tests for the genetic faults could allow early detection of recurrence of the tumour and of other cases of Wilms in the patient’s family.”
New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM
A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
26.04.2017 | Materials Sciences
26.04.2017 | Agricultural and Forestry Science
26.04.2017 | Physics and Astronomy