Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Scientists highlight link between stress and appetite

Researchers in the Hotchkiss Brain Institute (HBI) at the University of Calgary's Faculty of Medicine have uncovered a mechanism by which stress increases food drive in rats. This new discovery, published online this week in the journal Neuron, could provide important insight into why stress is thought to be one of the underlying contributors to obesity.

Normally, the brain produces neurotransmitters (chemicals responsible for how cells communicate in the brain) called endocannabinoids that send signals to control appetite. In this study, the researchers found that when food is not present, a stress response occurs that temporarily causes a functional re-wiring in the brain. This re-wiring may impair the endocannabinoids' ability to regulate food intake and could contribute to enhanced food drive.

The researchers also discovered that when they blocked the effects of stress hormones in the brain, the absence of food caused no change in the neural circuitry.

Researchers Jaideep Bains, Ph.D. and Quentin Pittman, Ph.D., looked specifically at nerve cells (neurons) in the region of the brain called the hypothalamus. This structure is known to have an important role in the control of appetite and metabolism and has been identified as the primary region responsible for the brain's response to stress.

Bains explains, "These findings could help explain how the cellular communication in our brains may be overridden in the absence of food. Interestingly, these changes are driven not necessarily by the lack of nutrients, but rather by the stress induced by the lack of food."

If similar changes occur in the human brain, these findings might have several implications for human health.

"For example, if we elect to pass over a meal, the brain appears to simply increase the drive in pathways leading to increased appetite," explains Pittman. "Furthermore, the fact that the lack of food causes activation of the stress response might help explain the relationship between stress and obesity."

These results lay the foundation for future studies to investigate the use of therapies that affect these systems in order to manipulate food intake. They also open the door to studies looking at whether or not the stress brought about by lack of food affects other systems where endocannabinoids are known to play a role.

"One thing we can say for sure, is that this research highlights the importance of food availability to our nervous system. The absence of food clearly brings about dramatic changes in the way our neurons communicate with each other," says Pittman.

This work was conducted jointly in the labs of Bains and Pittman and the experiments were carried out by Karen Crosby and Wataru Inoue, Ph.D. The research is supported by operating grants from the Canadian Institutes of Health Research (CIHR) and Alberta Innovates- Health Solutions (AI-HS).

Marta | EurekAlert!
Further information:

Further reports about: Bains Pittman food intake health services nerve cell stress hormone stress response

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>