Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Saturated fat intake may influence a person's expression of genetic obesity risk

05.06.2014

Limiting saturated fat could help people whose genetic make-up increases their chance of being obese.

In a new study, researchers from the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University identified 63 gene variants related to obesity and used them to calculate a genetic risk score for obesity for more than 2,800 white, American men and women enrolled in two large studies on heart disease prevention.

People with a higher genetic risk score, who also consumed more of their calories as saturated fat, were more likely to have a higher Body Mass Index (BMI), the ratio of body weight to height.

"We already know there are certain genes that interact with dietary fat and affect BMI," said senior author José M. Ordovás, Ph.D., director of the Nutrition and Genomics Laboratory at the USDA HNRCA and a professor at the Friedman School of Nutrition Science and Policy at Tufts University.

... more about:
»Academy »BMI »Dietary »Health »Nutrition »Translational »genes »obesity »risk

"In the current study, we analyzed dozens of variants of those genes and other genes frequently associated with obesity risk and saw that, while total fat intake was related to higher BMI, people who were genetically predisposed to obesity and ate the most saturated fat had the highest BMIs."

The findings, which account for possible confounding factors such as age, sex, and physical activity levels, are published online ahead of print in the Journal of the Academy of Nutrition and Dietetics.

Ordovás and colleagues hypothesize that people who have these gene variants that predispose them to obesity may be more sensitive to saturated fat, which is found mostly in fatty cuts of meats, including beef and pork, as well as butter, cheese and other high-fat dairy products.

"Little is known about the mechanisms that might explain the role of saturated fat intake in obesity," said Ordovás, who is also a member of the Genetics and Pharmacology & Experimental Therapeutics graduate program faculty at the Sackler School of Graduate Biomedical Sciences at Tufts University.

"Some clinical models suggest that saturated fat might interfere with activity in the part of the brain that lets us know we're full, in addition to a few studies in people that suggest a diet high in saturated fat interferes with satiety. More research is needed to know whether those findings would also apply to gene function."

Genetic risk score could be useful in identifying people who are predisposed to obesity and could ultimately lead to personalized dietary recommendations. "If further research can clarify a relationship between obesity related genes and saturated fat, people with higher scores would have even more incentive to follow advice to limit their saturated fat intake as part of an obesity prevention strategy," Ordovás said.

###

This research was supported by the National Institutes of Health (NIH) (grant nos. 1R21AR055228-01A1, HL54776, 5R21HL114238-02, and U01 HL72524); the National Institute of Diabetes and Digestive Kidney Diseases (NIDDK) (grant nos. DK063491 and DK075030); the U.S. Department of Agriculture Research Service (USDA ARS) (grant nos. 53-K06-5-10, 58–1950-9-001, and K08 HL112845-01); the National Center for Advancing Translational Sciences, Clinical and Translational Science Institute (grant no. UL1TR000124, and the European Union Seventh Framework Programme (grant agreement no. PIOF-GA-2010-272581).

Casas-Augustench, P et al. Saturated Fat Intake Modulates the Association between an Obesity Genetic Risk Score and Body Mass Index in Two U.S. Populations, Journal of the Academy of Nutrition and Dietetics, (Available online 2 May 2014, In Press, Corrected Proof), DOI: 10.1016/j.jand.2014.03.014

For three decades, the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University has studied the relationship between good nutrition and good health in aging populations. Tufts research scientists work with federal agencies to establish the USDA Dietary Guidelines, the Dietary Reference Intakes, and other significant public policies. The Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy at Tufts University is the only independent school of nutrition in the United States. The school's eight degree programs, which focus on questions relating to famine, hunger, poverty, and communications, are renowned for the application of scientific research to national and international policy.

Andrea Grossman | Eurek Alert!
Further information:
http://www.tufts.edu/

Further reports about: Academy BMI Dietary Health Nutrition Translational genes obesity risk

More articles from Health and Medicine:

nachricht Penn studies find promise for innovations in liquid biopsies
30.03.2017 | University of Pennsylvania School of Medicine

nachricht 'On-off switch' brings researchers a step closer to potential HIV vaccine
30.03.2017 | University of Nebraska-Lincoln

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

'On-off switch' brings researchers a step closer to potential HIV vaccine

30.03.2017 | Health and Medicine

Penn studies find promise for innovations in liquid biopsies

30.03.2017 | Health and Medicine

An LED-based device for imaging radiation induced skin damage

30.03.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>