New research in The FASEB Journal suggests that a short peptide called tylotoin exerts the promotion of wound healing with epidermal growth factor (EGF) in a murine model of a full thickness dermal wound
Move over antibiotic ointment, there might be a new salve to dominate medicine cabinets of the future, and it comes from an unlikely place—the lowly salamander. Salamanders may not be the cuddliest of animals, but they can regenerate lost limbs and achieve amazing recovery of seriously damaged body parts.
Now, a new report published in the September 2014 issue of The FASEB Journal, identifies a small protein (called a "peptide") from the skin of salamanders that may be the key to unlocking the secret of this amazing wound healing trick in humans.
"This research takes a step toward an understanding of the cellular and molecular events that underlie quick wound healing in the salamander by the discovery of a potential wound healing promoting peptide," said Ren Lai, Ph.D., a researcher involved in the work from the Kunming Institute of Zoology at the Chinese Academy of Sciences in Yunnan, China.
To make this discovery, Lai and colleagues collected skin extract from salamanders and separated it by gel filtration and high performance liquid chromatography. The skin component from salamanders was subjected to keratinocyte cell proliferation and endothelial cell tube formation assay to evaluate possible wound healing potential.
This component was further subjected to structure and functional analysis, which pointed toward a short peptide called tylotoin that contained 12 amino acid residues. This peptide was found to exert the ability to promote wound healing with epidermal growth factor (EGF) in a murine model of a full thickness dermal wound.
Tylotoin directly enhances the motility and proliferation of keratinocytes, vascular endothelial cells and fibroblasts, resulting in accelerated re-epithelialization and granulation tissue formation in the wound site. Tylotoin also promotes the release of transforming growth factor beta1 and interleukin 6, which are essential in the wound healing response.
"Until now, rapid wound healing has been the stuff of superheroes and science fiction," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Scientists have always wondered how some 'lower' animals heal wounds that would be mortal to humans. Now, we are taking concrete steps to mimic this ancient – and forgotten – healing process in our own bodies."
Receive monthly highlights from The FASEB Journal by e-mail. Sign up at http://www.faseb.org/fjupdate.aspx. The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). It is the world's most cited biology journal according to the Institute for Scientific Information and has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century.
FASEB is composed of 27 societies with more than 120,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.
Details: Lixian Mu, Jing Tang, Han Liu, Chuanbin Shen, Mingqiang Rong, Zhiye Zhang, and Ren Lai. A potential wound-healing-promoting peptide from salamander skin. FASEB J. September 2014 28:3919-3929; doi:10.1096/fj.13-248476 ; http://www.fasebj.org/content/28/9/3919.abstract
Cody Mooneyhan | Eurek Alert!
Penn study identifies viral product that promotes immune defense against RSV
04.09.2015 | University of Pennsylvania
Columbia Engineering team develops targeted drug delivery to lung
03.09.2015 | Columbia University School of Engineering and Applied Science
In a survey of NASA's Hubble Space Telescope images of 2,753 young, blue star clusters in the neighboring Andromeda galaxy (M31), astronomers have found that M31 and our own galaxy have a similar percentage of newborn stars based on mass.
By nailing down what percentage of stars have a particular mass within a cluster, or the Initial Mass Function (IMF), scientists can better interpret the light...
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE have developed a highly compact and efficient inverter for use in uninterruptible power...
China's Loess Plateau was formed by wind alternately depositing dust or removing dust over the last 2.6 million years, according to a new report from University of Arizona geoscientists. The study is the first to explain how the steep-fronted plateau formed.
China's Loess Plateau was formed by wind alternately depositing dust or removing dust over the last 2.6 million years, according to a new report from...
The leaves of the lotus flower, and other natural surfaces that repel water and dirt, have been the model for many types of engineered liquid-repelling surfaces. As slippery as these surfaces are, however, tiny water droplets still stick to them. Now, Penn State researchers have developed nano/micro-textured, highly slippery surfaces able to outperform these naturally inspired coatings, particularly when the water is a vapor or tiny droplets.
Enhancing the mobility of liquid droplets on rough surfaces could improve condensation heat transfer for power-plant heat exchangers, create more efficient...
Longer, more severe, and hotter droughts and a myriad of other threats, including diseases and more extensive and severe wildfires, are threatening to transform some of the world's temperate forests, a new study published in Science has found. Without informed management, some forests could convert to shrublands or grasslands within the coming decades.
"While we have been trying to manage for resilience of 20th century conditions, we realize now that we must prepare for transformations and attempt to ease...
03.09.2015 | Event News
20.08.2015 | Event News
20.08.2015 | Event News
04.09.2015 | Power and Electrical Engineering
04.09.2015 | Machine Engineering
04.09.2015 | Materials Sciences