It uses real human skin and immune cells to show any reaction such as a rash or blistering indicating a wider immune response within the body.
The development is timely as it offers a reliable alternative for the cosmetic industry as a ban on the sale of any cosmetic product tested on animals came into effect across Europe in March.
Professor Anne Dickinson from the Institute of Cellular Medicine recently presented the technology at the In-Vitro Testing Industrial Platform (IVTIP) conference in Brussels. She said: "This skin assay offers an accurate and rapid alternative to animal testing and provides the bridge between the laboratory tests for novel drugs and the first stage of clinical trials in humans.
"It is accurate and faster than anything currently around and can save companies time and resources. The test identifies drugs or products which are likely to cause a reaction or just not work effectively in humans."
The test called Skimune™, which is trademarked and has a patent pending, has been successfully tested by a number of large pharmaceutical companies on drugs in development and provides a reliable result within two weeks.
By revealing skin sensitisation or an adverse reaction that may not be identified by use of an animal or computer model, the assay can provide vital information which will allow a drug company to make informed decisions earlier saving significant development costs.
Professor Dickinson said: "We've already shown this works as a way of testing new drugs for adverse immune reactions that can't be identified when tested in animal models."
Working with the National Institute of Biological Standards and Control (NIBSC) the Newcastle team have been testing monoclonal antibodies for adverse responses. Professor Dickinson added: "Our Skimune™ test would have predicted the terrible outcome at Northwick Park in 2006. Then six men taking part in a clinical trial had severe reactions to a monoclonal antibody resulting in organ failure. Previous laboratory and animal research gave no indication that this was likely to occur.
"Our test would have picked up the risk because it is a skin-based model of the human immune response."
The skin assay has been developed using cells isolated from blood samples from a range of healthy volunteers. Differentiated into dendritic cells which activate the T-cells, these in turn create a cytokine storm. Useful for fighting infection, if this immune response goes unchecked it can be extremely harmful to the individual. Skimune™ provides a histology skin damage read out enabling the severity and potency of reaction to be gauged.
Professor Richard Stebbings, principle scientist at NIBSC welcomed the development adding: "This assay offers a valuable alternative to animal models, used for safety testing of biological medicines and which are often poorly predictive of human responses."
Professor Anne Dickinson has spent 20 years working to understand how we prevent the body rejecting donor tissue such as bone marrow. This technology has been developed from a skin explant model for predicting a potentially serious complication of bone marrow transplantation, 'graft versus host' disease - a common complication following the transplant.
It has been supported by the UK's innovation agency with a Technology Strategy Board grant for the development of a prototype.
As well as patent pending the Skimune™ test, the Newcastle University team have set up a company Alcyomics Limited which aims to take the technology forward to offer personalised medicine, enabling an individual to be tested for drug responses.
More information on the technology can be found on http://www.alcyomics.com.
Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München
Second cause of hidden hearing loss identified
20.02.2017 | Michigan Medicine - University of Michigan
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
22.02.2017 | Power and Electrical Engineering
22.02.2017 | Life Sciences
22.02.2017 | Physics and Astronomy