From 2006 to 2009, researchers examined the impact of the vaccine among children hospitalized for diarrhea and/or vomiting in the Cincinnati, Ohio; Nashville, Tenn.; and Rochester, N.Y., areas. In 2008, rotavirus hospitalizations among vaccine-eligible children decreased 87 to 96 percent.
Routine rotavirus vaccination of U.S. infants began in 2006, and children between the ages of 6 months and 24 months are eligible for the vaccine. During the pre-rotavirus vaccine era, rotavirus gastroenteritis was responsible for 4 to 5 percent of all U.S. pediatric hospitalizations and accounted for about 50 percent of acute gastroenteritis hospitalizations during the winter months.
According to study author Daniel C. Payne, MSPH, PhD, of the Centers for Disease Control and Prevention in Atlanta, "Our data confirm that the introduction of rotavirus vaccination among U.S. children has dramatically decreased rotavirus hospitalization rates. The reductions observed in 2008 far exceeded what was expected on the basis of vaccine coverage and effectiveness."
Even older children who were too old to have been immunized with rotavirus vaccine appeared to benefit. The hospitalization rate decreased 92 percent among these older, unvaccinated children and is believed to have been due to the indirect protective benefits conferred by reduced rotavirus transmission from younger, vaccinated children in the household and community. However, Dr. Payne noted, "The indirect protective benefits seen in older, unvaccinated children were not observed during the following year, 2009, when rotavirus rates increased disproportionately among this age group. These findings suggest that indirect protective benefits may have provided unvaccinated, older children a single-year deferral of exposure and illness.
"Continued surveillance is needed to further assess the role of rotavirus vaccination coverage, indirect protective benefits, immunity over time, and serotypic variation upon rotavirus activity in the United States," Dr. Payne said.
NOTE: The study is available online. It is embargoed until 12:01 a.m. EDT on Friday, June 24, 2011: Direct and Indirect Effects of Rotavirus Vaccination Upon Childhood Hospitalizations in 3 U.S. Counties, 2006� http://www.oxfordjournals.org/our_journals/cid/prpaper.pdf
Founded in 1979, Clinical Infectious Diseases publishes clinical articles twice monthly in a variety of areas of infectious disease, and is one of the most highly regarded journals in this specialty. It is published under the auspices of the Infectious Diseases Society of America (IDSA). Based in Arlington, Va., IDSA is a professional society representing more than 9,000 physicians and scientists who specialize in infectious diseases. For more information, visit www.idsociety.org.
John Heys | EurekAlert!
Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University
Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
24.02.2017 | Life Sciences
24.02.2017 | Life Sciences
24.02.2017 | Trade Fair News