A Cleveland Clinic research team is developing virtual models of human knee joints to better understand how tissues and their individual cells react to heavy loads – virtual models that someday can be used to understand damage mechanisms caused by the aging process or debilitating diseases, such as osteoarthritis.
A macro-scale model of the knee (left) was created to study compressive loading of the joint. At the micro scale, the single-cell model (top, right) has been used in previous studies, while Erdemir’s 11-cell model better represents the effects of loading on the individual cells. (Erdemir/Cleveland Clinic)
Erdemir’s finite element model of the knee joint with representation of the cartilage, menisci and the associated bone structures. An enlarged model region (right) illustrates the mesh resolution of the simulation. (Erdemir/Cleveland Clinic)
The Department of Biomedical Engineering (BME) at the Lerner Research Institute is committed to investigation, innovation, and translation of scientific discoveries to enhance patient care. The Lerner Research Institute is home to Cleveland Clinic's laboratory-based, translational and clinical research. For more, visit www.lerner.ccf.org/bme.
Jamie Abel | EurekAlert!
Further reports about: > Biomedical > Ferchau Engineering > LRI > Lerner > OSC > Osteoarthritis > Supercomputer > aging process > body-level scales > cartilage > cartilage cells > chondrocytes > computing system > debilitating disease > debilitating diseases > human body > knee joint > musculoskeletal mechanics > single cell > state-of-the-art computational representations
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