Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers study joints at tissue, cellular levels

25.07.2012
Cleveland Clinic team simulates cartilage response to loading

A Cleveland Clinic research team is developing virtual models of human knee joints to better understand how tissues and their individual cells react to heavy loads – virtual models that someday can be used to understand damage mechanisms caused by the aging process or debilitating diseases, such as osteoarthritis.


A macro-scale model of the knee (left) was created to study compressive loading of the joint. At the micro scale, the single-cell model (top, right) has been used in previous studies, while Erdemir’s 11-cell model better represents the effects of loading on the individual cells. (Erdemir/Cleveland Clinic)


Erdemir’s finite element model of the knee joint with representation of the cartilage, menisci and the associated bone structures. An enlarged model region (right) illustrates the mesh resolution of the simulation. (Erdemir/Cleveland Clinic)

Led by Ahmet Erdemir, Ph.D., the team is leveraging the powerful computing systems of the Ohio Supercomputer Center to develop state-of-the-art computational representations of the human body to understand how movement patterns and loads on the joints deform the surrounding tissues and cells. Erdemir is the director of the Computational Biomodeling Core (CoBi) and a faculty member in the Department of Biomedical Engineering at the Lerner Research Institute (LRI) in Cleveland, Ohio.

“The aging process and debilitating diseases affect many aspects of the mechanical function of the human body: from the way we move to how our muscles, joints, tissues, and cells accommodate the loading exerted on the body during daily activities,” Erdemir explained. “Computational modeling techniques provide an avenue to obtain additional insights about mechanics at various spatial scales.”
Many macro-scale studies have looked at how the various components of a knee joint – cartilage, menisci, ligaments and bone – respond to weight and other external loads. However, Erdemir and colleague Scott C. Sibole wanted to better understand how those large mechanical forces correspond to the related deformation of individual cartilage cells – or chondrocytes – within the knee. Previous micro-scale studies of cartilage have not commonly been based on data from body-level scales, in particular, by the musculoskeletal mechanics of the knee joint.

In addition, calculated deformations typically have been for a single cell at the center of a 100-cubic-micrometer block of simulated tissue; Erdemir used an anatomically based representation that calculated deformations for 11 cells distributed within the same volume.

“In both micro-scale approaches, the cartilage cells experienced amplified deformations compared to those at the macro-scale, predicted by simulating the compression of tissues in the knee joint under the weight of the body,” Erdemir found. “In the 11-cell case, all cells experienced less deformation than the single cell case, and also exhibited a larger variance in deformation compared to other cells residing in the same block.”

Erdemir’s method proved to be highly scalable because of micro-scale model independence that allowed exploitation of distributed memory computing architecture. As a result, Sibole, a research engineer at LRI, was able to leverage the computational muscle of OSC’s IBM 1350 Glenn Cluster. At the time, the 9,500 nodes of the Glenn Cluster provided 75 teraflops of computing power, tech-speak for 75 trillion calculations per second. Recently, the Glenn Cluster was partially decommissioned when engineers deployed the center’s more powerful HP-Intel Xeon Oakley Cluster.

“Both of OSC’s two most recent flagship computing systems were specifically designed to support biomedical applications, such as those employed by Dr. Erdemir and Mr. Sibole,” said Ashok Krishnamurthy, OSC interim co-executive director. “Researchers working at Ohio’s various respected medical centers are conducting an ever-increasing load of computational studies and analyses, and they now represent a significant share of our user community.”

An article authored by Erdemir and Sibole, “Chondrocyte Deformations as a Function of Tibiofemoral Joint Loading Predicted by a Generalized High-Throughput Pipeline of Multi-Scale Simulations,” was recently published in PLoS ONE, an international, peer-reviewed, open-access, online journal. Grant funding from the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health supported the study.

The Ohio Supercomputer Center (OSC), a member of the Ohio Technology Consortium of the Ohio Board of Regents, addresses the rising computational demands of academic and industrial research communities by providing a robust shared infrastructure and proven expertise in advanced modeling, simulation and analysis. OSC empowers scientists with the vital resources essential to make extraordinary discoveries and innovations, partners with businesses and industry to leverage computational science as a competitive force in the global knowledge economy, and leads efforts to equip the workforce with the key technology skills required to secure 21st century jobs. For more, visit www.osc.edu.

The Department of Biomedical Engineering (BME) at the Lerner Research Institute is committed to investigation, innovation, and translation of scientific discoveries to enhance patient care. The Lerner Research Institute is home to Cleveland Clinic's laboratory-based, translational and clinical research. For more, visit www.lerner.ccf.org/bme.

Jamie Abel | EurekAlert!
Further information:
http://www.oh-tech.org

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Strathclyde-led research develops world's highest gain high-power laser amplifier

The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.

The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Camera on NASA's Lunar Orbiter survived 2014 meteoroid hit

29.05.2017 | Physics and Astronomy

Strathclyde-led research develops world's highest gain high-power laser amplifier

29.05.2017 | Physics and Astronomy

A 3-D look at the 2015 El Niño

29.05.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>