Kessler Foundation researchers collaborate with colleagues in Spain to study memory deficits in Parkinson’s patients without dementia
Kessler Foundation scientists collaborated with colleagues in Spain to study memory and learning in patients with Parkinson Disease (PD). They found that the Parkinson group’s ability to learn new information was significantly poorer when compared with the control group. The article was published ahead of print on February 24: Chiaravalloti ND, Ibarretxe-Bilbao N, Deluca J, Rusu O, Pena J, García-Gorostiaga I, Ojeda N. The source of the memory impairment in Parkinson's disease: Acquisition versus retrieval. Movement Disorders 2014 Feb 24.
Nancy Chiaravalloti, PhD
Lead author Nancy Chiaravalloti, PhD, is the Foundation’s director of Neuropsychology, Neuroscience & Traumatic Brain Injury Research; John DeLuca, PhD, is senior VP of Research & Training. Their co-authors are affiliated with the University of Deusto, Bilbao, and Galdakao Hospital, Galdakao, Spain.
Memory deficits are common in persons with PD, even among those without frank dementia. “Traditionally, these deficits have been attributed to the patients’ inability to retrieve information from their long-term memory,” explained Dr. Chiaravalloti,” which is called the ‘retrieval failure hypothesis.’ Some studies, however, document problems that are inconsistent with the retrieval failure hypothesis.” To clarify the underlying mechanisms, this study focused specifically on learning abilities in a PD sample without dementia.
Researchers compared the performance of a PD group of 27 patients with a group of 27 matched healthy controls (HCs) on a neuropsychological test battery designed to assess new learning and memory. “We found a significant difference between the groups in their ability to learn a list of 10 semantically related words,” noted Dr. Chiaravalloti.
“However, no significant differences were seen between the PD and control groups in recall or recognition of newly learned material. We concluded that the memory deficit in patients with PD without dementia was caused by a deficit in learning new information. Improving new learning is an important factor to consider in the development of cognitive rehabilitation interventions in this population.”
This study was supported by Kessler Foundation and the Health Department of Basque Government (2011111117; to N.I.B) and the Spanish Ministry of Economy and Competitiveness (PSI2012-32441; to N.I.B.).
Scientists at Kessler Foundation conduct cognitive research to improve cognition in individuals with multiple sclerosis, traumatic brain injury (TBI), stroke and dementia. Funding is provided by grants from the National Institutes of Health, National Institute on Disability Rehabilitation Research, National MS Society, NJ Commission of Brain Injury Research, Consortium of MS Centers, Patterson Trust, the Department of Veterans Affairs, Children’s Specialized Hospital Foundation, Healthcare Foundation of New Jersey, Craig H. Neilsen Foundation and Kessler Foundation.
About Kessler Foundation
Kessler Foundation, a major nonprofit organization in the field of disability, is a global leader in rehabilitation research that seeks to improve cognition, mobility and long-term outcomes, including employment, for people with neurological disabilities caused by diseases and injuries of the brain and spinal cord. Kessler Foundation leads the nation in funding innovative programs that expand opportunities for employment for people with disabilities. For more information, visit KesslerFoundation.org.
Nancy Chiaravalloti, PhD | EurekAlert!
Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences
What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy