Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers find possible new treatment strategies for pancreatic cancer

04.03.2011
New University of Georgia research has identified a protein that can be modified to improve the effectiveness of one of the most common drugs used to treat pancreatic cancer.

The research, published in the March edition of the journal Cancer Research, found that a cell-surface protein called CNT1, which transports cancer-killing drugs into tumor cells, was reduced in function in two thirds of pancreatic tumors.

By improving the function of CNT1, the researchers increased the effectiveness of the cancer-killing drugs in pancreatic tumor cells derived from human patients, said lead-author Raj Govindarajan, assistant professor of pharmaceutical and biomedical sciences in the UGA College of Pharmacy.

"The transporter was failing to take up the drug, so there were a bunch of different drug-resistant tumor cells," said Govindarajan. "Therapies that restore CNT1 could increase the effectiveness of the drug by helping carry the drug into the cell."

The drug most commonly used to treat pancreatic cancer is called gemcitabine and works by entering into the DNA of cancer cells and stopping replication. Many pancreatic tumor cells are resistant to gemcitabine, which makes the disease very difficult to treat, explained Govindarajan.

The researchers identified different methods to enhance CNT1 function and slow growth of the tumor cells. They found that by using additional drugs that inhibit pathways that degrade CNT1, they could partially restore its normal function and transport more gemcitabine into the tumor cells to prevent proliferation of the tumor.

The researchers attained the same results by genetically augmenting CNT1. "We over-expressed this protein in tumor cells so that it is functional continuously throughout the cell cycle, and it took up a lot of the drug and facilitated tumor killing," said Govindarajan. "So it shows potential for therapeutic aspects."

Govindarajan and his colleagues also found that CNT1 was likely regulated by tiny RNA molecules called micro-RNAs. "Micro-RNAs are clearly emerging as a new paradigm in gene regulation," said Govindarajan. "We could potentially use micro-RNAs to increase CNT1 expression and increase tumor-cell targeting of gemcitabine."

The American Cancer Society estimates that 43,000 people will be diagnosed with pancreatic cancer every year, and about 85 percent of those will die within one year of diagnosis.

Govindarajan said that the findings need to be evaluated in laboratory animals for both effectiveness and toxicity aspects to determine if they are feasible therapeutic options. He hopes that future studies will confirm the possibilities of combining additional therapies with gemcitabine to more effectively treat pancreatic cancer. "What we are trying to do is see if we can improve the standard of care for treating pancreatic cancer," he said.

The study was funded by the National Cancer Institute and by the department of pharmaceutical and biomedical sciences at the University of Georgia.

For more information on the UGA College of Pharmacy, see http://www.rx.uga.edu/.

Raj Govindarajan | EurekAlert!
Further information:
http://www.uga.edu

Further reports about: CNT1 RNA molecule pancreatic cancer pancreatic tumor tumor cells

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>