Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers in Dresden succeed a break-through in diabetes therapy utilizing artificial pancreas

29.10.2013
Human beta cells of the islets of Langerhans utilized in a bio-reactor implant produced reliably insulin in a type 1 diabetes patient for a whole year - for the first time, researcher at the University Hospital Carl Gustav Carus Dresden, have demonstrated an artificial pancreas system. The implant restored the physiological function of insulin production in a type 1 diabetes patient.

The team of Professor Dr Stefan R. Bornstein, Director of the Department of Medicine III in Dresden, implanted the bio-reactor in a patient. The results of the first year are now published in the Journal of Proceedings of the National Academy of Sciences (PNAS 2013; doi:10.1073/pnas.1317561110).

The novel approach has the potential to replace the transplantation with subsequent immunosuppression. However, more research and a broader study is necessary before a large number of type 1 diabetes patients could benefit from this findings.

For the very first time ever, a patient with type 1 diabetes got an artificial pancreas system implanted which produces vital insulin in islet cells like in the pancreas. The small bio-reactor which looks like a little tin has been in the patient body for about one year. The artificial system which has been developed by an Israeli company supersedes an immunosuppression completely. The donor cells will be protected against immune system responses of the patient.

In reverse the insulin will be released into the body. Prof Bornstein, Director of the Department of Medicine III at the University Hospital: “The controlled supply of the cells with oxygen is vital to keep them alive.” He is convinced that the new system shall revolutionise the therapy of diabetes. Many more patients with diabetes type 1 will benefit from a transplantation of islet cells because the recipients do not need any immunosuppressive drugs for their lifetime.

„This is further proof of 20 years successful alliance of medical research and care in Dresden”, says Prof. Michael Albrecht, Medical Manager of the University Hospital Carl Gustav Carus. “This impressive result shows our demand implementing basic research in favour of our patients – the primary objective of the Medical Faculty in Dresden”, says Prof Dr Heinz Reichmann, dean of Medical Faculty Carl Gustav Carus of Technical University Dresden.

Nobel medicine winner Prof Andrew V. Schally of Miller School of Medicine at the University of Miami, who has a research collaboration with Dresden, pronounced “This is a success of historical meaning“. Despite medication, some patients with type 1 diabetes suffer of life threatening deviation of their glucose balance. Transplantation of pancreas as well as islet cells are the only two options to replace insulin producing beta cells and restore the physiological function of insulin production. Both options mean a considerably better control of diabetes and quality of life for the patient. However, the permanent taking of immunosuppressive drugs makes patients susceptible for infections and other adverse effects like a higher risk of cancer. Therefore, these treatments were considered for patients with special medical requirements only.

Dr Barbara Ludwig started the program of transplantation of human beta cells of the islets of Langerhans in 2008. It is the first and only centre of its kind in Germany. The main interest of Dr Ludwig’s group is the quality improvement of human beta cell transplantations. The artificial pancreas system was intensively tested in animals with the colleagues from Israel. The result of this cooperation project was recently published in Proceedings of the National Academy of Sciences (PNAS 2013; doi:10.1073/pnas.1317561110).

Surely, more work has to be done, but Prof Bornstein is certain that the new system will be a serious option in therapy of diabetes in five years time.

Contact:
University Hospital Carl Gustav Carus Dresden
Technical University Dresden
Department of Medicine III
Prof Dr Stefan R. Bornstein
Tel.: +49 351 458 5955
Fax: +49 351 458 6398
E-Mail: stefan.bornstein@uniklinkum-dresden.de

Susanne Witzigmann | idw
Further information:
http://www.uniklinkum-dresden.de

More articles from Health and Medicine:

nachricht Cholesterol-lowering drugs may fight infectious disease
22.08.2017 | Duke University

nachricht Once invincible superbug squashed by 'superteam' of antibiotics
22.08.2017 | University at Buffalo

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

What the world's tiniest 'monster truck' reveals

23.08.2017 | Life Sciences

Treating arthritis with algae

23.08.2017 | Life Sciences

Witnessing turbulent motion in the atmosphere of a distant star

23.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>