The team of Professor Dr Stefan R. Bornstein, Director of the Department of Medicine III in Dresden, implanted the bio-reactor in a patient. The results of the first year are now published in the Journal of Proceedings of the National Academy of Sciences (PNAS 2013; doi:10.1073/pnas.1317561110).
The novel approach has the potential to replace the transplantation with subsequent immunosuppression. However, more research and a broader study is necessary before a large number of type 1 diabetes patients could benefit from this findings.
For the very first time ever, a patient with type 1 diabetes got an artificial pancreas system implanted which produces vital insulin in islet cells like in the pancreas. The small bio-reactor which looks like a little tin has been in the patient body for about one year. The artificial system which has been developed by an Israeli company supersedes an immunosuppression completely. The donor cells will be protected against immune system responses of the patient.
In reverse the insulin will be released into the body. Prof Bornstein, Director of the Department of Medicine III at the University Hospital: “The controlled supply of the cells with oxygen is vital to keep them alive.” He is convinced that the new system shall revolutionise the therapy of diabetes. Many more patients with diabetes type 1 will benefit from a transplantation of islet cells because the recipients do not need any immunosuppressive drugs for their lifetime.
„This is further proof of 20 years successful alliance of medical research and care in Dresden”, says Prof. Michael Albrecht, Medical Manager of the University Hospital Carl Gustav Carus. “This impressive result shows our demand implementing basic research in favour of our patients – the primary objective of the Medical Faculty in Dresden”, says Prof Dr Heinz Reichmann, dean of Medical Faculty Carl Gustav Carus of Technical University Dresden.
Nobel medicine winner Prof Andrew V. Schally of Miller School of Medicine at the University of Miami, who has a research collaboration with Dresden, pronounced “This is a success of historical meaning“. Despite medication, some patients with type 1 diabetes suffer of life threatening deviation of their glucose balance. Transplantation of pancreas as well as islet cells are the only two options to replace insulin producing beta cells and restore the physiological function of insulin production. Both options mean a considerably better control of diabetes and quality of life for the patient. However, the permanent taking of immunosuppressive drugs makes patients susceptible for infections and other adverse effects like a higher risk of cancer. Therefore, these treatments were considered for patients with special medical requirements only.
Dr Barbara Ludwig started the program of transplantation of human beta cells of the islets of Langerhans in 2008. It is the first and only centre of its kind in Germany. The main interest of Dr Ludwig’s group is the quality improvement of human beta cell transplantations. The artificial pancreas system was intensively tested in animals with the colleagues from Israel. The result of this cooperation project was recently published in Proceedings of the National Academy of Sciences (PNAS 2013; doi:10.1073/pnas.1317561110).
Surely, more work has to be done, but Prof Bornstein is certain that the new system will be a serious option in therapy of diabetes in five years time.Contact:
Susanne Witzigmann | idw
Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center
Overdosing on Calcium
19.06.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
19.06.2018 | Physics and Astronomy
19.06.2018 | Life Sciences
19.06.2018 | Physics and Astronomy