Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers Develop Novel Cancer Detection Method

09.11.2009
A novel method of detection of cervical cancer cells has been developed by Clarkson University Professor Igor Sokolov’s group, an affiliate of the University’s Nanoengineering and Biotechnology Laboratories Center (NABLAB).

The group's paper, "Towards Nonspecific Detection of Malignant Cervical Cells with Fluorescent Silica Beads," is published in Small (Volume 5 Issue 20, Pages 2,277 - 2,284).

Methods for detection of cancer cells are mostly based on traditional techniques used in biology, such as visual identification of malignant changes, cell-growth analysis or genetic tests.

Despite being well developed, these methods are either insufficiently accurate or require a lengthy complicated analysis, which is impractical for clinical use.

Sokolov and his team hope that the physical sciences can help to develop an alternative method in the detection of cancer cells, which will be more precise and simpler.

His group reports in Small on a method to detect cancer cells by using nonspecific (just physical) adhesion of silica beads to cells.

This finding is based on their recently published results in Nature Nanotechnology, where they reported on observation of unknown before difference in surface physical properties of cancerous and normal human epithelial cervical cells. Specifically, they found a substantial difference in the brush layer on the cell surface. This difference was the main motivation for their present work. The difference in the brush was expected to lead to the differences in the adhesion of various particles to such cells.

The adhesion was studied with the help of atomic force microscopy (AFM). Silica beads were attached to the AFM cantilever, and consequently, touched the cell surfaces. The force needed to separate the bead from the cell, the adhesion force, was measured.

The difference in adhesion, which has an essentially physical nature, was used to distinguish between cancerous and normal cells. High adhesion resulted in more particles adhered to cells. Utilizing fluorescent silica particle, one can easily measure the amount of fluorescent light coming from such cells.

The researchers used ultrabright fluorescent silica particles − the brightest particles ever synthesized -- also developed by Sokolov's team. Using cells collected from cervical cancers of three cancer patients and cells extracted from tissue of healthy patients, the researchers found an unambiguous difference.

This achievement can lead to earlier detection and treatment of cancer, which is important to decrease fatality of this disease considerably.

While this finding might advance to novel methods in diagnosis and treatment, including improved speed, convenience and accuracy, Sokolov says “The problem is in the variability of human subjects. The difference was found for six human subjects. This might be enough for a demonstration, but it is not sufficient to speak about a new clinical method. More statistics must be collected before we can speak about clinical applications.” As the team prepares a more detailed summary of results, he and Biology Professor Craig Woodworth are writing a proposal for further study to the National Institutes of Health.

The team consists of Sokolov, who has appointments in Physics, Chemistry and Biomolecular Science; Woodworth, a cervical cancer expert; Maxim Dokukin, a physics postdoctoral fellow; and Ravi M. Gaikwad and Nataliaa Guz, physics graduate students. The other members of Sokolov’s group, Eun-Bum Cho (physics postdoctoral fellow), and physics graduate students Dmytro Volkov and Shyuzhene Li, work on biosensors, self-assembly of particles, and the study of skin aging.

The research was done within the Nanoengineering and Biotechnology Laboratories Center (NABLAB) led by Sokolov, a unit established to promote cross-disciplinary collaborations within the University. It comprises more than a dozen faculty members to capitalize on the expertise of Clarkson scholars in the areas of cancer cell research, fine particles for bio and medical applications, synthesis of smart materials, advancement biosensors, etc.

Clarkson University launches leaders into the global economy. One in six alumni already leads as a CEO, VP or equivalent senior executive of a company. Located just outside the Adirondack Park in Potsdam, N.Y., Clarkson is a nationally recognized research university for undergraduates with select graduate programs in signature areas of academic excellence directed toward the world’s pressing issues. Through 50 rigorous programs of study in engineering, business, arts, sciences and health sciences, the entire learning-living community spans boundaries across disciplines, nations and cultures to build powers of observation, challenge the status quo, and connect discovery and engineering innovation with enterprise.

Michael P. Griffin | Newswise Science News
Further information:
http://www.clarkson.edu

More articles from Health and Medicine:

nachricht Tracking movement of immune cells identifies key first steps in inflammatory arthritis
23.01.2017 | Massachusetts General Hospital

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>