Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers Develop Novel Cancer Detection Method

09.11.2009
A novel method of detection of cervical cancer cells has been developed by Clarkson University Professor Igor Sokolov’s group, an affiliate of the University’s Nanoengineering and Biotechnology Laboratories Center (NABLAB).

The group's paper, "Towards Nonspecific Detection of Malignant Cervical Cells with Fluorescent Silica Beads," is published in Small (Volume 5 Issue 20, Pages 2,277 - 2,284).

Methods for detection of cancer cells are mostly based on traditional techniques used in biology, such as visual identification of malignant changes, cell-growth analysis or genetic tests.

Despite being well developed, these methods are either insufficiently accurate or require a lengthy complicated analysis, which is impractical for clinical use.

Sokolov and his team hope that the physical sciences can help to develop an alternative method in the detection of cancer cells, which will be more precise and simpler.

His group reports in Small on a method to detect cancer cells by using nonspecific (just physical) adhesion of silica beads to cells.

This finding is based on their recently published results in Nature Nanotechnology, where they reported on observation of unknown before difference in surface physical properties of cancerous and normal human epithelial cervical cells. Specifically, they found a substantial difference in the brush layer on the cell surface. This difference was the main motivation for their present work. The difference in the brush was expected to lead to the differences in the adhesion of various particles to such cells.

The adhesion was studied with the help of atomic force microscopy (AFM). Silica beads were attached to the AFM cantilever, and consequently, touched the cell surfaces. The force needed to separate the bead from the cell, the adhesion force, was measured.

The difference in adhesion, which has an essentially physical nature, was used to distinguish between cancerous and normal cells. High adhesion resulted in more particles adhered to cells. Utilizing fluorescent silica particle, one can easily measure the amount of fluorescent light coming from such cells.

The researchers used ultrabright fluorescent silica particles − the brightest particles ever synthesized -- also developed by Sokolov's team. Using cells collected from cervical cancers of three cancer patients and cells extracted from tissue of healthy patients, the researchers found an unambiguous difference.

This achievement can lead to earlier detection and treatment of cancer, which is important to decrease fatality of this disease considerably.

While this finding might advance to novel methods in diagnosis and treatment, including improved speed, convenience and accuracy, Sokolov says “The problem is in the variability of human subjects. The difference was found for six human subjects. This might be enough for a demonstration, but it is not sufficient to speak about a new clinical method. More statistics must be collected before we can speak about clinical applications.” As the team prepares a more detailed summary of results, he and Biology Professor Craig Woodworth are writing a proposal for further study to the National Institutes of Health.

The team consists of Sokolov, who has appointments in Physics, Chemistry and Biomolecular Science; Woodworth, a cervical cancer expert; Maxim Dokukin, a physics postdoctoral fellow; and Ravi M. Gaikwad and Nataliaa Guz, physics graduate students. The other members of Sokolov’s group, Eun-Bum Cho (physics postdoctoral fellow), and physics graduate students Dmytro Volkov and Shyuzhene Li, work on biosensors, self-assembly of particles, and the study of skin aging.

The research was done within the Nanoengineering and Biotechnology Laboratories Center (NABLAB) led by Sokolov, a unit established to promote cross-disciplinary collaborations within the University. It comprises more than a dozen faculty members to capitalize on the expertise of Clarkson scholars in the areas of cancer cell research, fine particles for bio and medical applications, synthesis of smart materials, advancement biosensors, etc.

Clarkson University launches leaders into the global economy. One in six alumni already leads as a CEO, VP or equivalent senior executive of a company. Located just outside the Adirondack Park in Potsdam, N.Y., Clarkson is a nationally recognized research university for undergraduates with select graduate programs in signature areas of academic excellence directed toward the world’s pressing issues. Through 50 rigorous programs of study in engineering, business, arts, sciences and health sciences, the entire learning-living community spans boundaries across disciplines, nations and cultures to build powers of observation, challenge the status quo, and connect discovery and engineering innovation with enterprise.

Michael P. Griffin | Newswise Science News
Further information:
http://www.clarkson.edu

More articles from Health and Medicine:

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

nachricht How to turn white fat brown
07.12.2016 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

NTU scientists build new ultrasound device using 3-D printing technology

07.12.2016 | Health and Medicine

The balancing act: An enzyme that links endocytosis to membrane recycling

07.12.2016 | Life Sciences

How to turn white fat brown

07.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>