Antibacterial orthodontic cement containing a quaternary ammonium monomer dimethylaminododecyl methacrylate
Today, at the 43rd Annual Meeting & Exhibition of the American Association for Dental Research (AADR), held in conjunction with the 38th Annual Meeting of the Canadian Association for Dental Research, Mary Anne Sampaio de Melo, from the University of Maryland, Baltimore, will present a research study titled "Antibacterial Orthodontic Cement Containing a Quaternary Ammonium Monomer Dimethylaminododecyl Methacrylate."
Demineralized lesions in enamel around orthodontic brackets are caused by acids from biofilm accumulation. The objectives of this study were to develop a novel antibacterial orthodontic bracket cement by incorporating a quaternary ammonium monomer dimethylaminododecyl methacrylate (DMADDM), and to investigate the effects on dental plaque microcosm biofilm response and enamel bond strength.
DMADDM with an alkyl chain length of 12 was synthesized and incorporated into the cement at mass fractions of 0%, 1.5% and 3%. Orthodontic cement Transbond XT served as control. Shear bond strength of metal brackets to human enamel was measured.
Cement remnant index scores were determined after bracket failure. A plaque microcosm biofilm model with human saliva as inoculum was used to measure metabolic activity, lactic acid production, and colony-forming units (CFU) for biofilms on orthodontic cements.
Incorporating DMADDM into orthodontic cement did not affect the shear bond strength (13.1 to 14.6 MPa; p = 0.09). Dental plaque microcosm biofilm viability was substantially inhibited when in contact with cement disks containing DMADDM. The new orthodontic adhesive reduced biofilm metabolic activity by up to 66% and lactic acid by 78% (p < 0.05). Biofilm total micro-organisms were reduced by up to 88%, total streptococci by 96%, and mutans streptococci by 98% (p < 0.05).
Increasing DMADDM mass fraction increased the antibacterial potency. Orthodontic cement containing 3% DMADDM was the most strongly antibacterial. These results show that the DMADDM-containing orthodontic cement inhibited biofilms and lactic acid without compromising the enamel bond strength, and hence may be promising to reduce or eliminate demineralization in enamel around orthodontic brackets.
This is a summary of abstract #1327, "Antibacterial Orthodontic Cement Containing a Quaternary Ammonium Monomer Dimethylaminododecyl Methacrylate," to be presented by Mary Anne Sampaio de Melo, Saturday, March 22, 2014, from 8 a.m. – 9:30 a.m. at the Charlotte Convention Center, room 213BC.
About the American Association for Dental Research
The American Association for Dental Research (AADR), headquartered in Alexandria, Va., is a nonprofit organization with more than 3,600 members in the United States. Its mission is: (1) to advance research and increase knowledge for the improvement of oral health; (2) to support and represent the oral health research community; and (3) to facilitate the communication and application of research findings. AADR is the largest Division of the International Association for Dental Research (IADR). To learn more about the AADR, visit http://www.aadr.org
Ingrid L. Thomas | EurekAlert!
Using DNA origami to build nanodevices of the future
31.08.2015 | Institute for Integrated Cell-Material Sciences at Kyoto University
An ounce of prevention: Research advances on 'scourge' of transplant wards
28.08.2015 | University of Wisconsin-Madison
China's Loess Plateau was formed by wind alternately depositing dust or removing dust over the last 2.6 million years, according to a new report from University of Arizona geoscientists. The study is the first to explain how the steep-fronted plateau formed.
China's Loess Plateau was formed by wind alternately depositing dust or removing dust over the last 2.6 million years, according to a new report from...
The leaves of the lotus flower, and other natural surfaces that repel water and dirt, have been the model for many types of engineered liquid-repelling surfaces. As slippery as these surfaces are, however, tiny water droplets still stick to them. Now, Penn State researchers have developed nano/micro-textured, highly slippery surfaces able to outperform these naturally inspired coatings, particularly when the water is a vapor or tiny droplets.
Enhancing the mobility of liquid droplets on rough surfaces could improve condensation heat transfer for power-plant heat exchangers, create more efficient...
Longer, more severe, and hotter droughts and a myriad of other threats, including diseases and more extensive and severe wildfires, are threatening to transform some of the world's temperate forests, a new study published in Science has found. Without informed management, some forests could convert to shrublands or grasslands within the coming decades.
"While we have been trying to manage for resilience of 20th century conditions, we realize now that we must prepare for transformations and attempt to ease...
A University of Oklahoma astrophysicist and his Chinese collaborator have found two supermassive black holes in Markarian 231, the nearest quasar to Earth, using observations from NASA's Hubble Space Telescope.
The discovery of two supermassive black holes--one larger one and a second, smaller one--are evidence of a binary black hole and suggests that supermassive...
A team of European researchers have developed a model to simulate the impact of tsunamis generated by earthquakes and applied it to the Eastern Mediterranean. The results show how tsunami waves could hit and inundate coastal areas in southern Italy and Greece. The study is published today (27 August) in Ocean Science, an open access journal of the European Geosciences Union (EGU).
Though not as frequent as in the Pacific and Indian oceans, tsunamis also occur in the Mediterranean, mainly due to earthquakes generated when the African...
20.08.2015 | Event News
20.08.2015 | Event News
19.08.2015 | Event News
02.09.2015 | Physics and Astronomy
02.09.2015 | Studies and Analyses
02.09.2015 | Physics and Astronomy