Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers determine why tendons break down with age

05.08.2014

Scientists at Queen Mary University of London (QMUL) have identified differences in the proteins present in young and old tendons, in new research that could guide the development of treatments to stop tissue breakdown from occurring.

Tendon structure in horses is similar to humans, and both face common injuries. The researchers used a horse model to undertake a thorough analysis of all the proteins and protein fragments present in healthy and injured tendons. 

Working with scientists at the University of Liverpool, the team collected data, which shows that healthy, older tendons have a greater amount of fragmented material within them, suggesting accumulated damage over time that has not been fully repaired. 

When examining injured tendons, the team found even more evidence of protein breakdown. However, whilst in younger tendons, the cells were active and trying to repair the damage, there was an accumulation of different protein fragments in older tendons. This suggests the cells somehow lose the ability to repair damage during the ageing process. 

... more about:
»ability »ageing »damage »fragments »healthy »injury »proteins »repair »tendon

“Normal function of tendons, such as the Achilles, is important not just for Commonwealth athletes but for everyday activities for ordinary people,” said co-author Dr Hazel Screen, a Reader in biomedical engineering at QMUL’s  School of Engineering and Materials Science and Institute of Bioengineering

She added: “This is the first study of its kind, and provides evidence that the increased risk of tendon injury with ageing might be due to a reduced ability of tendon cells to repair damage effectively.”   

This novel information is an important first step towards understanding how our tissues break down as we age and could help us find ways to prevent it occurring in the future. 

Proteomic analysis reveals age-related changes in tendon matrix composition, with age-and injury-specific matrix fragmentation’ is published in the Journal of Biological Chemistry.

 

For more information or to arrange interviews with the author, please contact:

Neha Okhandiar

Public Relations Manager - Science and Engineering

T: +44 (0)207 882 7927

E: n.okhandiar@qmul.ac.uk

Queen Mary University of London                         

Queen Mary University of London is the “biggest star” (Times Higher Education) among the UK's leading research-intensive higher education institutions, with five campuses in the capital: Mile End, Whitechapel, Charterhouse Square, West Smithfield and Lincoln’s Inn Fields. 

A member of the Russell Group, QMUL is also one of the largest of the colleges of the University of London, with 17,800 students - 20 per cent of whom are from more than 150 countries. 

Some 4,000 staff deliver world-class degrees and research across 21 departments, within three Faculties: Science and Engineering; Humanities and Social Sciences; and the School of Medicine and Dentistry.

Neha Okhandiar | Queen Mary University of London (QMUL)
Further information:
http://www.qmul.ac.uk

Further reports about: ability ageing damage fragments healthy injury proteins repair tendon

More articles from Health and Medicine:

nachricht Nanotubes are beacons in cancer-imaging technique
23.05.2016 | Rice University

nachricht More light on cancer
20.05.2016 | Lomonosov Moscow State University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Atomic precision: technologies for the next-but-one generation of microchips

In the Beyond EUV project, the Fraunhofer Institutes for Laser Technology ILT in Aachen and for Applied Optics and Precision Engineering IOF in Jena are developing key technologies for the manufacture of a new generation of microchips using EUV radiation at a wavelength of 6.7 nm. The resulting structures are barely thicker than single atoms, and they make it possible to produce extremely integrated circuits for such items as wearables or mind-controlled prosthetic limbs.

In 1965 Gordon Moore formulated the law that came to be named after him, which states that the complexity of integrated circuits doubles every one to two...

Im Focus: Researchers demonstrate size quantization of Dirac fermions in graphene

Characterization of high-quality material reveals important details relevant to next generation nanoelectronic devices

Quantum mechanics is the field of physics governing the behavior of things on atomic scales, where things work very differently from our everyday world.

Im Focus: Graphene: A quantum of current

When current comes in discrete packages: Viennese scientists unravel the quantum properties of the carbon material graphene

In 2010 the Nobel Prize in physics was awarded for the discovery of the exceptional material graphene, which consists of a single layer of carbon atoms...

Im Focus: Transparent - Flexible - Printable: Key technologies for tomorrow’s displays

The trend-forward world of display technology relies on innovative materials and novel approaches to steadily advance the visual experience, for example through higher pixel densities, better contrast, larger formats or user-friendler design. Fraunhofer ISC’s newly developed materials for optics and electronics now broaden the application potential of next generation displays. Learn about lower cost-effective wet-chemical printing procedures and the new materials at the Fraunhofer ISC booth # 1021 in North Hall D during the SID International Symposium on Information Display held from 22 to 27 May 2016 at San Francisco’s Moscone Center.

Economical processing

Im Focus: Trojan horses for hospital bugs

Staphylococcus aureus usually is a formidable bacterial pathogen. Sometimes, however, weakened forms are found in the blood of patients. Researchers of the University of Würzburg have now identified one mutation responsible for that phenomenon.

Staphylococcus aureus is a bacterium that is frequently found on the human skin and in the nose where it usually behaves inconspicuously. However, once inside...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Networking 4.0: International Laser Technology Congress AKL’16 Shows New Ways of Cooperations

24.05.2016 | Event News

Challenges of rural labor markets

20.05.2016 | Event News

International expert meeting “Health Business Connect” in France

19.05.2016 | Event News

 
Latest News

Rutgers scientists help create world's largest coral gene database

24.05.2016 | Earth Sciences

New technique controls autonomous vehicles on a dirt track

24.05.2016 | Information Technology

Programmable materials find strength in molecular repetition

24.05.2016 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>