Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research says TB infection may be underestimated among people taking corticosteroid pills

26.06.2014

More screening may be needed

Tuberculosis infection among people taking corticosteroid pills may be underestimated, new research suggests. Current guidelines for what constitutes a positive TB skin test among corticosteroid pill users may not be capturing all those who are infected, said


Current guidelines for what constitutes a positive TB skin test among corticosteroid pill users may not be capturing all those who are infected, said Dr. Nicholas Vozoris, a respirologist in the Tuberculosis Program at St. Michael's Hospital.

Credit: Courtesy of St. Michael's Hospital

Dr. Nicholas Vozoris, a respirologist in the Tuberculosis Program at St. Michael's Hospital.

Previous research has shown that people who take corticosteroid pills, such as Prednisone, and have inhaled the TB bacteria, have an eight times higher risk of the bacteria becoming active than people who are not taking the drugs.

Dr. Vozoris said that would suggest they should be screened more often for TB infection.

However, an examination of more than 7,300 people in the U.S. National Health and Nutrition Examination Survey found this was not the case. The survey, a series of studies designed to assess the health and nutritional status of adults and children in the United States, is unique in that it combines interviews and physical examinations.

The findings were published today in the European Respiratory Journal.

He found that although taking corticosteroid pills was a risk factor for turning latent TB into active TB, those patients were screened less often for TB than others. They were also less likely to be prescribed TB-fighting drugs prophylactically.

Dr. Vozoris said that for the general population, producing a bump at least 10 millimetres in diameter following a TB skin test likely means that one has inhaled the TB bacteria. Current guidelines recommend that the bump be only five millimetres long if the patient is taking corticosteroid pills, but Dr. Vozoris said there is no evidence to support that is the correct cut-off. The study results show that 3.5-mm might be a more appropriate cut-off.

Corticosteroid pills are commonly prescribed for people with asthma, chronic obstructive pulmonary disease, inflammatory bowel disease, inflammatory arthritis and cancer. They work by decreasing inflammation, but they also suppress the immune system.

The Respirology Division of St. Michael's Hospital has a Tuberculosis Program dedicated exclusively to caring for patients with TB disease and infection. The program's clinic has 1,900 patient visits a year, making it one of the largest TB clinics in Canada.

###

About St. Michael's Hospital

St. Michael's Hospital provides compassionate care to all who enter its doors. The hospital also provides outstanding medical education to future health care professionals in 27 academic disciplines. Critical care and trauma, heart disease, neurosurgery, diabetes, cancer care, care of the homeless and global health are among the hospital's recognized areas of expertise. Through the Keenan Research Centre and the Li Ka Shing International Healthcare Education Centre, which make up the Li Ka Shing Knowledge Institute, research and education at St. Michael's Hospital are recognized and make an impact around the world. Founded in 1892, the hospital is fully affiliated with the University of Toronto

Contact information

For more information or to interview Dr. Vozoris, contact:

Leslie Shepherd
Manager, Media Strategy,
Phone: 416-864-6094 or 647-300-1753
shepherdl@smh.ca
St. Michael's Hospital
Inspired Care. Inspiring Science.
http://www.stmichaelshospital.com
Follow us on Twitter: http://www.twitter.com/stmikeshospital

Leslie Shepherd | Eurek Alert!

Further reports about: TB Tuberculosis bacteria corticosteroid diameter drugs guidelines inflammatory skin

More articles from Health and Medicine:

nachricht Mobile phone test can reveal vision problems in time
11.02.2016 | University of Gothenburg

nachricht Proteomics and precision medicine
08.02.2016 | University of Iowa Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Production of an AIDS vaccine in algae

Today, plants and microorganisms are heavily used for the production of medicinal products. The production of biopharmaceuticals in plants, also referred to as “Molecular Pharming”, represents a continuously growing field of plant biotechnology. Preferred host organisms include yeast and crop plants, such as maize and potato – plants with high demands. With the help of a special algal strain, the research team of Prof. Ralph Bock at the Max Planck Institute of Molecular Plant Physiology in Potsdam strives to develop a more efficient and resource-saving system for the production of medicines and vaccines. They tested its practicality by synthesizing a component of a potential AIDS vaccine.

The use of plants and microorganisms to produce pharmaceuticals is nothing new. In 1982, bacteria were genetically modified to produce human insulin, a drug...

Im Focus: The most accurate optical single-ion clock worldwide

Atomic clock experts from the Physikalisch-Technische Bundesanstalt (PTB) are the first research group in the world to have built an optical single-ion clock which attains an accuracy which had only been predicted theoretically so far. Their optical ytterbium clock achieved a relative systematic measurement uncertainty of 3 E-18. The results have been published in the current issue of the scientific journal "Physical Review Letters".

Atomic clock experts from the Physikalisch-Technische Bundesanstalt (PTB) are the first research group in the world to have built an optical single-ion clock...

Im Focus: Goodbye ground control: autonomous nanosatellites

The University of Würzburg has two new space projects in the pipeline which are concerned with the observation of planets and autonomous fault correction aboard satellites. The German Federal Ministry of Economic Affairs and Energy funds the projects with around 1.6 million euros.

Detecting tornadoes that sweep across Mars. Discovering meteors that fall to Earth. Investigating strange lightning that flashes from Earth's atmosphere into...

Im Focus: Flow phenomena on solid surfaces: Physicists highlight key role played by boundary layer velocity

Physicists from Saarland University and the ESPCI in Paris have shown how liquids on solid surfaces can be made to slide over the surface a bit like a bobsleigh on ice. The key is to apply a coating at the boundary between the liquid and the surface that induces the liquid to slip. This results in an increase in the average flow velocity of the liquid and its throughput. This was demonstrated by studying the behaviour of droplets on surfaces with different coatings as they evolved into the equilibrium state. The results could prove useful in optimizing industrial processes, such as the extrusion of plastics.

The study has been published in the respected academic journal PNAS (Proceedings of the National Academy of Sciences of the United States of America).

Im Focus: New study: How stable is the West Antarctic Ice Sheet?

Exceeding critical temperature limits in the Southern Ocean may cause the collapse of ice sheets and a sharp rise in sea levels

A future warming of the Southern Ocean caused by rising greenhouse gas concentrations in the atmosphere may severely disrupt the stability of the West...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Travel grants available: Meet the world’s most proficient mathematicians and computer scientists

09.02.2016 | Event News

AKL’16: Experience Laser Technology Live in Europe´s Largest Laser Application Center!

02.02.2016 | Event News

From intelligent knee braces to anti-theft backpacks

26.01.2016 | Event News

 
Latest News

New method opens crystal clear views of biomolecules

11.02.2016 | Life Sciences

Scientists take nanoparticle snapshots

11.02.2016 | Physics and Astronomy

NASA sees development of Tropical Storm 11P in Southwestern Pacific

11.02.2016 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>