Osteoarthritis is a common, degenerative, joint disease that increases in prevalence with age. During the disease, the matrix structure comprising cartilage in the joints is significantly diminished, inflicting severe frictional pain and restricting joint movement. One reason for this phenomenon is reduced matrix production and gene expression.
SirT1 is a nuclear enzyme that regulates the expression of many genes through alterations in chromatin structure. Chromatin is the combination of DNA and other proteins that make up the contents of the cell nucleus.
In laboratory work carried out at the Laboratory of Cartilage Biology at the Hebrew University of Jerusalem Faculty of Dental Medicine, researchers headed by Dr. Mona Dvir-Ginzberg showed that SirT1 positively regulates the expression of many cartilage-tissue components. Her work was carried out in cooperation with researchers at the US National Institutes of Health in Bethesda, MD.
This data, published in the Arthritis and Rheumatism journal, showed that when there is joint inflammation, SirT1 degenerates and is inactivated, thereby accelerating joint destruction through altered gene expression.
Understanding these events will enable the design of drug targets to serve as potential therapies that may retard or reverse OA through possibly boosting SirT1 production. Additionally, testing of SirT1 levels could serve as an early indicator for OA susceptibility and thus serve as a signal for beginning timely treatment.
"Developing a combined strategy for diagnosis and treatment, based on these data, could provide an efficient alternative for joint replacement surgery and enable susceptible individuals to experience a better quality of life for years to come," said Dr Dvir-Ginzberg.
Jerry Barach | Hebrew University of Jerusalem
NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)
High speed video recording precisely measures blood cell velocity
15.11.2017 | ITMO University
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
17.11.2017 | Physics and Astronomy
17.11.2017 | Health and Medicine
17.11.2017 | Studies and Analyses