Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research provides promise for better dealing with osteoarthritis

23.11.2011
A step towards better understanding of the biological mechanism involved in the onset of osteoarthritis (OA), which affects millions of people around the world, has been shown in research carried out at the Hebrew University of Jerusalem and in the United States.

Osteoarthritis is a common, degenerative, joint disease that increases in prevalence with age. During the disease, the matrix structure comprising cartilage in the joints is significantly diminished, inflicting severe frictional pain and restricting joint movement. One reason for this phenomenon is reduced matrix production and gene expression.

SirT1 is a nuclear enzyme that regulates the expression of many genes through alterations in chromatin structure. Chromatin is the combination of DNA and other proteins that make up the contents of the cell nucleus.

In laboratory work carried out at the Laboratory of Cartilage Biology at the Hebrew University of Jerusalem Faculty of Dental Medicine, researchers headed by Dr. Mona Dvir-Ginzberg showed that SirT1 positively regulates the expression of many cartilage-tissue components. Her work was carried out in cooperation with researchers at the US National Institutes of Health in Bethesda, MD.

This data, published in the Arthritis and Rheumatism journal, showed that when there is joint inflammation, SirT1 degenerates and is inactivated, thereby accelerating joint destruction through altered gene expression.

Understanding these events will enable the design of drug targets to serve as potential therapies that may retard or reverse OA through possibly boosting SirT1 production. Additionally, testing of SirT1 levels could serve as an early indicator for OA susceptibility and thus serve as a signal for beginning timely treatment.

"Developing a combined strategy for diagnosis and treatment, based on these data, could provide an efficient alternative for joint replacement surgery and enable susceptible individuals to experience a better quality of life for years to come," said Dr Dvir-Ginzberg.

For further information:
Jerry Barach, Dept. of Media Relations, the Hebrew University,
Tel: 02-588-2904.
Orit Sulitzeanu, Hebrew University spokesperson, Tel: 054-8820016.

Jerry Barach | Hebrew University of Jerusalem
Further information:
http://www.huji.ac.il

More articles from Health and Medicine:

nachricht Malaria Already Endemic in the Mediterranean by the Roman Period
27.07.2017 | Universität Zürich

nachricht Serious children’s infections also spreading in Switzerland
26.07.2017 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Physicists Design Ultrafocused Pulses

Physicists working with researcher Oriol Romero-Isart devised a new simple scheme to theoretically generate arbitrarily short and focused electromagnetic fields. This new tool could be used for precise sensing and in microscopy.

Microwaves, heat radiation, light and X-radiation are examples for electromagnetic waves. Many applications require to focus the electromagnetic fields to...

Im Focus: Carbon Nanotubes Turn Electrical Current into Light-emitting Quasi-particles

Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers

Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...

Im Focus: Flexible proximity sensor creates smart surfaces

Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.

At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

 
Latest News

Programming cells with computer-like logic

27.07.2017 | Life Sciences

Identified the component that allows a lethal bacteria to spread resistance to antibiotics

27.07.2017 | Life Sciences

Malaria Already Endemic in the Mediterranean by the Roman Period

27.07.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>