Osteoarthritis is a common, degenerative, joint disease that increases in prevalence with age. During the disease, the matrix structure comprising cartilage in the joints is significantly diminished, inflicting severe frictional pain and restricting joint movement. One reason for this phenomenon is reduced matrix production and gene expression.
SirT1 is a nuclear enzyme that regulates the expression of many genes through alterations in chromatin structure. Chromatin is the combination of DNA and other proteins that make up the contents of the cell nucleus.
In laboratory work carried out at the Laboratory of Cartilage Biology at the Hebrew University of Jerusalem Faculty of Dental Medicine, researchers headed by Dr. Mona Dvir-Ginzberg showed that SirT1 positively regulates the expression of many cartilage-tissue components. Her work was carried out in cooperation with researchers at the US National Institutes of Health in Bethesda, MD.
This data, published in the Arthritis and Rheumatism journal, showed that when there is joint inflammation, SirT1 degenerates and is inactivated, thereby accelerating joint destruction through altered gene expression.
Understanding these events will enable the design of drug targets to serve as potential therapies that may retard or reverse OA through possibly boosting SirT1 production. Additionally, testing of SirT1 levels could serve as an early indicator for OA susceptibility and thus serve as a signal for beginning timely treatment.
"Developing a combined strategy for diagnosis and treatment, based on these data, could provide an efficient alternative for joint replacement surgery and enable susceptible individuals to experience a better quality of life for years to come," said Dr Dvir-Ginzberg.
Jerry Barach | Hebrew University of Jerusalem
Advanced analysis of brain structure shape may track progression to Alzheimer's disease
26.10.2016 | Massachusetts General Hospital
Indian roadside refuse fires produce toxic rainbow
26.10.2016 | Duke University
Physicists from the University of Würzburg have designed a light source that emits photon pairs. Two-photon sources are particularly well suited for tap-proof data encryption. The experiment's key ingredients: a semiconductor crystal and some sticky tape.
So-called monolayers are at the heart of the research activities. These "super materials" (as the prestigious science magazine "Nature" puts it) have been...
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
28.10.2016 | Power and Electrical Engineering
28.10.2016 | Physics and Astronomy
28.10.2016 | Life Sciences