Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research identifies a promising new therapeutic target for aggressive breast cancer

01.08.2012
Scientists at Western University have identified a new therapeutic target for advanced breast cancer which has shown tremendous promise in mouse models.

The study led by Lynne-Marie Postovit of Western's Schulich School of Medicine & Dentistry looked at a protein called Nodal that is primarily found in embryonic or stem cells. Postovit discovered high levels of this protein in aggressive breast cancer tumors. Nodal was found to promote vascularization in the tumor, providing nutrients and oxygen to help it grow and spread. The research is published online in the journal Cancer Research.

"We have determined that breast cancers, specifically those very aggressive, invasive breast cancers that spread, express an embryonic protein called Nodal and the expression of this protein is correlated with more blood vessels in the tumor. Blood vessels, many studies have shown, help to allow tumors to grow but also to spread throughout the body," says Postovit of the Department of Anatomy and Cell Biology. "In addition, we have shown that if we can target this embryonic protein, we can cause the blood vessels to collapse within the tumor, leading to decreased oxygen levels and tumor cell death. When tumors lack oxygen and nutrients they become what we call necrotic."

In the study, mouse models were designed to develop breast cancer tumors. Then, using a genetic modification, the researchers turned off the expression of Nodal. When they did that, the blood vessels in the tumor appeared to collapse, and the tumor was less aggressive. Nodal is on the outside of the cell, so it can be easily targeted by a number of mechanisms including antibodies. And because Nodal isn't expressed in normal tissue in the body, it would be possible to target just the cancer, allowing for better patient outcomes.

"Ultimately it would be nice to target Nodal in patients who already have quite advanced, well-vascularized tumors as a new option for therapy," says Daniela Quail, first author on the research and a PhD candidate in the Postovit lab. "Currently, patients like this don't have many options."

"In Canada, breast cancer continues to be one of the most common forms of cancer in women. Although new treatment methods have improved outcomes, a significant number of women still die from this disease", says Dr. Morag Park, Scientific Director of the Canadian Institutes of Health Research. "Research advancements, such as Dr. Postovit's, have contributed and will continue to contribute to the improvements around our understanding of cancer progression and treatment. I congratulate Dr. Postovit and the team on this advancement and its significant contribution to this field."

The research was funded by the Canadian Institutes of Health Research, the Cancer Research Society and the Canadian Breast Cancer Foundation.

Media contact: Jeff Renaud, Senior Media Relations Officer, Western University, 519-661-2111 ext. 85165, jrenaud9@uwo.ca

Jeff Renaud | EurekAlert!
Further information:
http://www.uwo.ca

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>