Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research finds new cause for common lung problem

07.05.2013
New research has found that in cases of lung edema, or fluid in the lungs, not only do the lungs fail to keep water out as previously believed, but they are also allowing water to pump in.

"Usually, our lungs pump fluid out of the air space, and it was previously believed that this pump mechanism just stopped when people had lung edema," said Dr. Wolfgang Kuebler, a scientist at St. Michael's Hospital. "But we've found not only do they stop pumping fluid out as they're supposed to do, they've gotten confused and are actually pumping in the reverse direction, bringing fluid into the lungs."

The research was published online in Proceedings of the National Academy of Sciences of the United States of America.

Dr. Kuebler said this finding has important implications for the treatment of lung edema, a common symptom of heart disease. Stopping the pumping mechanism, although seemingly counterintuitive, is protective for the lung and important for effective treatment.

For the first time, this explains why Lasix, a commonly prescribed drug, works in treating lung edema – it simply prevents the pumps from allowing fluid into the air spaces. Lasix was previously believed to work exclusively by targeting the kidneys.

"With this information, more effective drugs that target just the lungs, and not the kidneys, can now be developed," said Dr. Kuebler, also a scientist at the Li Ka Shing Knowledge Institute.

Dr. Kuebler points out that this mechanism of pumping fluid into the air spaces is similar to what happens in the fetal lung. In the womb, the lung works to pump fluids in and only after the baby is born, does that pumping mechanism reverse itself to pump fluid out. "You can actually now interpret lung edema as a regression of the adult lung to a fetal stage," he said.

This research was funded by a Boehringer Ingelheim MD fellowship and a Canadian Institutes of Health Research grant.

Kate Taylor | EurekAlert!
Further information:
http://www.smh.ca

Further reports about: air spaces common lung problem fluid in the lungs lung edema

More articles from Health and Medicine:

nachricht Monitoring the heart's mitochondria to predict cardiac arrest?
21.09.2017 | Boston Children's Hospital

nachricht Highly precise wiring in the Cerebral Cortex
21.09.2017 | Max-Planck-Institut für Hirnforschung

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Comet or asteroid? Hubble discovers that a unique object is a binary

21.09.2017 | Physics and Astronomy

Cnidarians remotely control bacteria

21.09.2017 | Life Sciences

Monitoring the heart's mitochondria to predict cardiac arrest?

21.09.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>