Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research confirms efficacy of the newly reclassified TMN staging system

11.01.2010
Represents most drastic change to cancer staging in the past 30 years
Research released in the January 2010 issue of the Journal of Thoracic Oncology sought to determine and validate the efficacy of the recent reclassification of the T category in the IASLC's Staging Manual in Thoracic Oncology.

The medical records of 1,393 patients with non-small cell lung cancer who underwent complete resection were thoroughly reviewed for pathologic findings and survival. The stage of all the patients was pathologically defined according to the present international staging system, previously revised in 1997. This study examined the relationship between the cut-off points of the tumor size for the new T category and the pathologic invasiveness

The tumor, node and metastatis (TNM) staging system is useful for both the clinical assessment of tumor progression and the determination of treatment plan (e.g., surgery, chemotherapy, radiation). In the forthcoming TNM classification, a revision with respect to lung cancer has been proposed by the International Association for the Study of Lung Cancer. The major revision is the T category, which makes an especially strict division by detailed cut points of tumor size (e.g., 2-, 3-, 5- and 7-cm). The proposed T revision has been determined and validated based on the overall survival date from a large international database.

Five-Year Postoperative Survival According to Primary Tumor Size, Presented by New T Category:

Classification Primary Tumor Size 5-Year Postoperative Survival
T1a ¡Ü 2 cm 78.0%
T1b >2 ¨C ¡Ü3 cm 63.3%
T2a >3 ¨C ¡Ü5 cm 46.4%
T2b >5 ¨C ¡Ü7 cm 38.8%
T3 >7 cm 21.4%
"The new T classification, which is based mainly on the tumor size, is therefore considered to be appropriate for the pathologic findings of the primary tumor," lead study author, Dr. Yano, summarizes the significance of the research findings. Furthermore, significant differences were observed among newly revised T subsets in at least one incidence of pathologic invasiveness, i.e. lymphatic, vascular, or pleural invasion.

Past chair and author of the IASLC's staging guide, Dr. Peter Goldstraw, confirms that "Any new addition to TMN is very important to the clinicians and researchers involved in that particular organ site. It happens that in the 6th edition there were no changes to TMN in lung cancer so this is very important; it's the first revision of TMN classification in lung cancer for 12 years. Indeed, it represents the most drastic change there has been in the past 30 years."

Dr. Goldstraw recently hosted an international roundtable explaining the changes applying to both clinical and patient perspectives of the staging revisions. Acknowledging the ongoing commitment, Dr Goldstraw explains that the "IASLC now has a responsibility to continue this central role in the formation of future classification of TMN and we have plans to build on the success of our process to improve among further revisions."

To listen to the Webcast, please visit: http://www.spectrumscience.com/iaslc-lung-cancer-staging-presentation.html

Journal of Thoracic Oncology (JTO) ¨C (journals.lww.com/jto)

The JTO is rapidly becoming a prized resource for medical specialists and scientists who focus on the detection, prevention, diagnosis and treatment of lung cancer. The JTO is the official monthly journal of the International Association for the Study of Lung Cancer (IASLC.org) and emphasizes a multidisciplinary approach, including original research (clinical trials and translational or basic research), reviews and opinion pieces.

Megan Richter | EurekAlert!
Further information:
http://www.spectrumscience.com

Further reports about: Cancer Goldstraw IASLC JTO Oncology Postoperative TMN TNM Thoracic lung cancer

More articles from Health and Medicine:

nachricht On track to heal leukaemia
18.01.2017 | Universitätsspital Bern

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

How gut bacteria can make us ill

18.01.2017 | Life Sciences

On track to heal leukaemia

18.01.2017 | Health and Medicine

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>